FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058366932> ?p ?o ?g. }

• W2058366932 endingPage "12125" @default.
• W2058366932 startingPage "12119" @default.
• W2058366932 abstract "Mixtures of dsDNA and lipids, so-called lipoplexes, are widely used as less toxic alternatives to viral vectors in transfection studies. However, the transfection efficiency achieved by lipoplexes is significantly lower than that of viral vectors and is a barrier to their use in the clinic. There is now significant evidence suggesting that the molecular organization and structure (nanoarchitecture) of lipoplexes might correlate with biological activity. As a consequence, the ability to predict quantitatively the nanoarchitecture of new systems, and how these might change intracellularly, would be a major tool in the development of rational discovery strategies for more efficient lipoplex formulations. Here we report the use of a coarse-grain molecular dynamics simulation to predict the phases formed by two lipoplex systems: dsDNA-DOPE and dsDNA-DOPE-DOTAP. The predictions of the simulations show excellent agreement with experimental data from polarized light microscopy and small-angle X-ray diffraction (SAXS); the simulations predicted the formation of phases with d-spacings that were comparable to those measured by SAXS. More significantly, the simulations were able to reproduce for the first time the experimentally observed change from a fluid lamellar to an inverse hexagonal phase in the dsDNA-DOPE-DOTAP system as a function of changes in lipid composition. Our studies indicate that coarse-grain MD simulations could provide a powerful tool to understand, and hence design, new lipoplex systems." @default.
• W2058366932 created "2016-06-24" @default.
• W2058366932 creator A5009321266 @default.
• W2058366932 creator A5014541016 @default.
• W2058366932 creator A5072744650 @default.
• W2058366932 creator A5079670006 @default.
• W2058366932 creator A5023390804 @default.
• W2058366932 date "2010-06-28" @default.
• W2058366932 modified "2023-09-27" @default.
• W2058366932 title "DNA Lipoplexes: Formation of the Inverse Hexagonal Phase Observed by Coarse-Grained Molecular Dynamics Simulation" @default.
• W2058366932 cites W1973579525 @default.
• W2058366932 cites W1974965014 @default.
• W2058366932 cites W1978180388 @default.
• W2058366932 cites W1981021420 @default.
• W2058366932 cites W1999698653 @default.
• W2058366932 cites W2004286543 @default.
• W2058366932 cites W2008632715 @default.
• W2058366932 cites W2010152588 @default.
• W2058366932 cites W2020902306 @default.
• W2058366932 cites W2022885635 @default.
• W2058366932 cites W2038302435 @default.
• W2058366932 cites W2043901383 @default.
• W2058366932 cites W2045101135 @default.
• W2058366932 cites W2048208860 @default.
• W2058366932 cites W2049286183 @default.
• W2058366932 cites W2061417691 @default.
• W2058366932 cites W2073545090 @default.
• W2058366932 cites W2079185419 @default.
• W2058366932 cites W2079416519 @default.
• W2058366932 cites W2082755780 @default.
• W2058366932 cites W2092770422 @default.
• W2058366932 cites W2093795463 @default.
• W2058366932 cites W2099563132 @default.
• W2058366932 cites W2105822696 @default.
• W2058366932 cites W2105957209 @default.
• W2058366932 cites W2107091035 @default.
• W2058366932 cites W2115442536 @default.
• W2058366932 cites W2117739601 @default.
• W2058366932 cites W2119267663 @default.
• W2058366932 cites W2121940055 @default.
• W2058366932 cites W2123768693 @default.
• W2058366932 cites W2124506958 @default.
• W2058366932 cites W2125313703 @default.
• W2058366932 cites W2157990526 @default.
• W2058366932 cites W2164730735 @default.
• W2058366932 cites W2165652738 @default.
• W2058366932 doi "https://doi.org/10.1021/la101448m" @default.
• W2058366932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20578750" @default.
• W2058366932 hasPublicationYear "2010" @default.
• W2058366932 type Work @default.
• W2058366932 sameAs 2058366932 @default.
• W2058366932 citedByCount "35" @default.
• W2058366932 countsByYear W20583669322012 @default.
• W2058366932 countsByYear W20583669322013 @default.
• W2058366932 countsByYear W20583669322014 @default.
• W2058366932 countsByYear W20583669322015 @default.
• W2058366932 countsByYear W20583669322016 @default.
• W2058366932 countsByYear W20583669322017 @default.
• W2058366932 countsByYear W20583669322018 @default.
• W2058366932 countsByYear W20583669322019 @default.
• W2058366932 countsByYear W20583669322020 @default.
• W2058366932 countsByYear W20583669322021 @default.
• W2058366932 countsByYear W20583669322022 @default.
• W2058366932 countsByYear W20583669322023 @default.
• W2058366932 crossrefType "journal-article" @default.
• W2058366932 hasAuthorship W2058366932A5009321266 @default.
• W2058366932 hasAuthorship W2058366932A5014541016 @default.
• W2058366932 hasAuthorship W2058366932A5023390804 @default.
• W2058366932 hasAuthorship W2058366932A5072744650 @default.
• W2058366932 hasAuthorship W2058366932A5079670006 @default.
• W2058366932 hasConcept C104317684 @default.
• W2058366932 hasConcept C120665830 @default.
• W2058366932 hasConcept C121332964 @default.
• W2058366932 hasConcept C12554922 @default.
• W2058366932 hasConcept C128765274 @default.
• W2058366932 hasConcept C131888329 @default.
• W2058366932 hasConcept C147597530 @default.
• W2058366932 hasConcept C159467904 @default.
• W2058366932 hasConcept C171250308 @default.
• W2058366932 hasConcept C178790620 @default.
• W2058366932 hasConcept C185592680 @default.
• W2058366932 hasConcept C191486275 @default.
• W2058366932 hasConcept C192562407 @default.
• W2058366932 hasConcept C2780134926 @default.
• W2058366932 hasConcept C41625074 @default.
• W2058366932 hasConcept C44280652 @default.
• W2058366932 hasConcept C53105671 @default.
• W2058366932 hasConcept C54009773 @default.
• W2058366932 hasConcept C55493867 @default.
• W2058366932 hasConcept C59593255 @default.
• W2058366932 hasConcept C77851909 @default.
• W2058366932 hasConcept C8010536 @default.
• W2058366932 hasConcept C86803240 @default.
• W2058366932 hasConceptScore W2058366932C104317684 @default.
• W2058366932 hasConceptScore W2058366932C120665830 @default.
• W2058366932 hasConceptScore W2058366932C121332964 @default.
• W2058366932 hasConceptScore W2058366932C12554922 @default.
• W2058366932 hasConceptScore W2058366932C128765274 @default.

• next