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- W2058367091 endingPage "160" @default.
- W2058367091 startingPage "153" @default.
- W2058367091 abstract "Activation of metabotropic glutamate 2 (mGlu2) receptors inhibits pain transmission at the synapses between primary afferent fibers and neurons in the dorsal horn of the spinal cord. In addition, mGlu2 receptors are found in peripheral nociceptors, and in pain-regulatory centers of the brain stem and forebrain. mGlu2 receptor agonists produce analgesia in models of inflammatory and neuropathic pain, but their use is limited by the development of tolerance. A new therapeutic strategy could be based on the transcriptional regulation of mGlu2 receptors via the acetylation-promoted activation of the p65/RelA transcription factor. Epigenetic drugs that increase mGlu2 receptor expression, including l-acetylcarnitine and inhibitors of histone deacetylases, have a different analgesic profile with no tolerance to the therapeutic effect after repeated dosing." @default.
- W2058367091 created "2016-06-24" @default.
- W2058367091 creator A5006363718 @default.
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- W2058367091 creator A5037965588 @default.
- W2058367091 creator A5056468131 @default.
- W2058367091 creator A5062403608 @default.
- W2058367091 creator A5083505605 @default.
- W2058367091 date "2010-04-01" @default.
- W2058367091 modified "2023-10-14" @default.
- W2058367091 title "Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain" @default.
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