FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058367789> ?p ?o ?g. }

• W2058367789 endingPage "689" @default.
• W2058367789 startingPage "679" @default.
• W2058367789 abstract "The delayed immune response to stroke is responsible for the increased neural injury that continues to occur after the initial ischemic event. This delayed immune response has been linked to the spleen, as splenectomy prior to middle cerebral artery occlusion (MCAO) is neuroprotective. Interferon gamma (IFNγ) is linked to the splenic response, which enhances neural injury following MCAO. IFNγ activates the expression of the inflammatory chemokine interferon-inducible protein 10 (IP-10). This study was designed to determine the role of IFNγ signaling in the inflammatory response following MCAO. Expression of IP-10 increased in the brain and the spleen following MCAO. Splenectomy inhibited the increase of IP-10 in the brain post-MCAO, while recombinant IFNγ administration to splenectomized rats returned IP-10 levels in the brain to levels found in rats after MCAO only. Systemic administration of an IFNγ neutralizing antibody to MCAO-treated rats reduced infarct volume and IP-10 levels in the brain. T cell infiltration was reduced in the MCAO-damaged brains of IFNγ antibody-treated animals relative to those that received isotype control antibodies. Additionally, inhibiting IFNγ signaling with splenectomy or an IFNγ neutralizing antibody blocked the induction of IP-10 expression and decreased neurodegeneration following MCAO. Targeting this pro-inflammatory pathway following stroke could be a promising stroke therapeutic." @default.
• W2058367789 created "2016-06-24" @default.
• W2058367789 creator A5003316044 @default.
• W2058367789 creator A5018693332 @default.
• W2058367789 creator A5019150773 @default.
• W2058367789 creator A5027536474 @default.
• W2058367789 creator A5046216623 @default.
• W2058367789 creator A5054520863 @default.
• W2058367789 date "2014-08-08" @default.
• W2058367789 modified "2023-09-30" @default.
• W2058367789 title "Pro-Inflammatory Interferon Gamma Signaling is Directly Associated with Stroke Induced Neurodegeneration" @default.
• W2058367789 cites W1966194847 @default.
• W2058367789 cites W1970341486 @default.
• W2058367789 cites W1973879471 @default.
• W2058367789 cites W1982702072 @default.
• W2058367789 cites W1988100193 @default.
• W2058367789 cites W1994363249 @default.
• W2058367789 cites W1994387916 @default.
• W2058367789 cites W2000775111 @default.
• W2058367789 cites W2010929029 @default.
• W2058367789 cites W2018259739 @default.
• W2058367789 cites W2040579356 @default.
• W2058367789 cites W2043508445 @default.
• W2058367789 cites W2046747192 @default.
• W2058367789 cites W2059050443 @default.
• W2058367789 cites W2074510736 @default.
• W2058367789 cites W2084147470 @default.
• W2058367789 cites W2094736478 @default.
• W2058367789 cites W2097756768 @default.
• W2058367789 cites W2107091908 @default.
• W2058367789 cites W2112505121 @default.
• W2058367789 cites W2134768631 @default.
• W2058367789 cites W2135936181 @default.
• W2058367789 cites W2138152051 @default.
• W2058367789 cites W2138451147 @default.
• W2058367789 cites W2159103481 @default.
• W2058367789 cites W2162787683 @default.
• W2058367789 doi "https://doi.org/10.1007/s11481-014-9560-2" @default.
• W2058367789 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4209188" @default.
• W2058367789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25104571" @default.
• W2058367789 hasPublicationYear "2014" @default.
• W2058367789 type Work @default.
• W2058367789 sameAs 2058367789 @default.
• W2058367789 citedByCount "78" @default.
• W2058367789 countsByYear W20583677892014 @default.
• W2058367789 countsByYear W20583677892015 @default.
• W2058367789 countsByYear W20583677892016 @default.
• W2058367789 countsByYear W20583677892017 @default.
• W2058367789 countsByYear W20583677892018 @default.
• W2058367789 countsByYear W20583677892019 @default.
• W2058367789 countsByYear W20583677892020 @default.
• W2058367789 countsByYear W20583677892021 @default.
• W2058367789 countsByYear W20583677892022 @default.
• W2058367789 countsByYear W20583677892023 @default.
• W2058367789 crossrefType "journal-article" @default.
• W2058367789 hasAuthorship W2058367789A5003316044 @default.
• W2058367789 hasAuthorship W2058367789A5018693332 @default.
• W2058367789 hasAuthorship W2058367789A5019150773 @default.
• W2058367789 hasAuthorship W2058367789A5027536474 @default.
• W2058367789 hasAuthorship W2058367789A5046216623 @default.
• W2058367789 hasAuthorship W2058367789A5054520863 @default.
• W2058367789 hasBestOaLocation W20583677892 @default.
• W2058367789 hasConcept C13373296 @default.
• W2058367789 hasConcept C159654299 @default.
• W2058367789 hasConcept C203014093 @default.
• W2058367789 hasConcept C25498285 @default.
• W2058367789 hasConcept C2776309230 @default.
• W2058367789 hasConcept C2779261636 @default.
• W2058367789 hasConcept C2780841837 @default.
• W2058367789 hasConcept C2780931953 @default.
• W2058367789 hasConcept C71924100 @default.
• W2058367789 hasConcept C8891405 @default.
• W2058367789 hasConcept C98274493 @default.
• W2058367789 hasConceptScore W2058367789C13373296 @default.
• W2058367789 hasConceptScore W2058367789C159654299 @default.
• W2058367789 hasConceptScore W2058367789C203014093 @default.
• W2058367789 hasConceptScore W2058367789C25498285 @default.
• W2058367789 hasConceptScore W2058367789C2776309230 @default.
• W2058367789 hasConceptScore W2058367789C2779261636 @default.
• W2058367789 hasConceptScore W2058367789C2780841837 @default.
• W2058367789 hasConceptScore W2058367789C2780931953 @default.
• W2058367789 hasConceptScore W2058367789C71924100 @default.
• W2058367789 hasConceptScore W2058367789C8891405 @default.
• W2058367789 hasConceptScore W2058367789C98274493 @default.
• W2058367789 hasIssue "5" @default.
• W2058367789 hasLocation W20583677891 @default.
• W2058367789 hasLocation W20583677892 @default.
• W2058367789 hasLocation W20583677893 @default.
• W2058367789 hasLocation W20583677894 @default.
• W2058367789 hasOpenAccess W2058367789 @default.
• W2058367789 hasPrimaryLocation W20583677891 @default.
• W2058367789 hasRelatedWork W2005666125 @default.
• W2058367789 hasRelatedWork W2015825435 @default.
• W2058367789 hasRelatedWork W2050374169 @default.
• W2058367789 hasRelatedWork W2070463916 @default.
• W2058367789 hasRelatedWork W2081358646 @default.
• W2058367789 hasRelatedWork W2094495174 @default.
• W2058367789 hasRelatedWork W2383775094 @default.

• next