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- W2058374336 abstract "Objective: To explore relationships between wake- and sleep-related health behaviors and circulating concentrations of inflammatory markers (interleukin [IL]-6 and tumor necrosis factor [TNF]-α) in a cohort of community dwelling older adults. Low-grade chronic inflammation is an important risk factor for age-related morbidity. Health behaviors, including average aggregate measures of sleep, have been linked to increased inflammation in older adults. Variability in sleep timing may also be associated with increased inflammation. Method: Participants were community dwelling older adults ≥60 years (n = 222: 39 bereaved, 55 caregivers, 52 with insomnia, and 76 good sleepers). Mean values and intraindividual variability in sleep, as well as caffeine and alcohol use, exercise, and daytime napping, were assessed by sleep diaries. Blood samples were obtained in the morning. Results: Several interactions were noted between sleep behaviors, inflammatory markers, and participant group. Greater variability in wake time and time in bed was associated with higher IL-6 among good sleepers relative to caregivers and older adults with insomnia. Good sleepers who consumed moderate amounts of alcohol had the lowest concentrations of IL-6 compared with the other three groups who consumed alcohol. Insomnia subjects, but not good sleepers, showed increased concentrations of IL-6 associated with caffeine use. Caregivers showed increased concentrations of TNF-α with alcohol use relative to good sleepers. Greater variability in bedtime, later wake times, and longer time in bed was associated with higher TNF-α regardless of group. Conclusions: Moderation and regularity in the practice of certain health behaviors, including sleep practices, were associated with lower plasma levels of inflammatory markers in older adults. Life circumstances and specific sleep disorders may modify these associations. WT = wake time; BT = bed time; TIB = time in bed." @default.
- W2058374336 created "2016-06-24" @default.
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- W2058374336 date "2011-02-01" @default.
- W2058374336 modified "2023-10-01" @default.
- W2058374336 title "Sleep Variability, Health-Related Practices, and Inflammatory Markers in a Community Dwelling Sample of Older Adults" @default.
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- W2058374336 doi "https://doi.org/10.1097/psy.0b013e3182020d08" @default.
- W2058374336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3106426" @default.
- W2058374336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21097658" @default.
- W2058374336 hasPublicationYear "2011" @default.
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