Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058374433> ?p ?o ?g. }
- W2058374433 endingPage "2464" @default.
- W2058374433 startingPage "2455" @default.
- W2058374433 abstract "Abstract Glioblastoma multiforme (GBM) is the most aggressive brain tumor that, by virtue of its resistance to chemotherapy and radiotherapy, is currently incurable. Identification of molecules whose targeting may eliminate GBM cells and/or sensitize glioblastoma cells to cytotoxic drugs is therefore urgently needed. CD44 is a major cell surface hyaluronan receptor and cancer stem cell marker that has been implicated in the progression of a variety of cancer types. However, the major downstream signaling pathways that mediate its protumor effects and the role of CD44 in the progression and chemoresponse of GBM have not been established. Here we show that CD44 is upregulated in GBM and that its depletion blocks GBM growth and sensitizes GBM cells to cytotoxic drugs in vivo. Consistent with this observation, CD44 antagonists potently inhibit glioma growth in preclinical mouse models. We provide the first evidence that CD44 functions upstream of the mammalian Hippo signaling pathway and that CD44 promotes tumor cell resistance to reactive oxygen species–induced and cytotoxic agent–induced stress by attenuating activation of the Hippo signaling pathway. Together, our results identify CD44 as a prime therapeutic target for GBM, establish potent antiglioma efficacy of CD44 antagonists, uncover a novel CD44 signaling pathway, and provide a first mechanistic explanation as to how upregulation of CD44 may constitute a key event in leading to cancer cell resistance to stresses of different origins. Finally, our results provide a rational explanation for the observation that functional inhibition of CD44 augments the efficacy of chemotherapy and radiation therapy. Cancer Res; 70(6); 2455–64" @default.
- W2058374433 created "2016-06-24" @default.
- W2058374433 creator A5007648823 @default.
- W2058374433 creator A5043636220 @default.
- W2058374433 creator A5049546733 @default.
- W2058374433 date "2010-03-14" @default.
- W2058374433 modified "2023-10-16" @default.
- W2058374433 title "CD44 Attenuates Activation of the Hippo Signaling Pathway and Is a Prime Therapeutic Target for Glioblastoma" @default.
- W2058374433 cites W1974673111 @default.
- W2058374433 cites W1980725734 @default.
- W2058374433 cites W2006890212 @default.
- W2058374433 cites W2010552629 @default.
- W2058374433 cites W2017647336 @default.
- W2058374433 cites W2022243451 @default.
- W2058374433 cites W2027238998 @default.
- W2058374433 cites W2027275036 @default.
- W2058374433 cites W2033987226 @default.
- W2058374433 cites W2035321569 @default.
- W2058374433 cites W2037632318 @default.
- W2058374433 cites W2039872271 @default.
- W2058374433 cites W2040385253 @default.
- W2058374433 cites W2040388882 @default.
- W2058374433 cites W2043029667 @default.
- W2058374433 cites W2045306157 @default.
- W2058374433 cites W2052268015 @default.
- W2058374433 cites W2052521454 @default.
- W2058374433 cites W2060020667 @default.
- W2058374433 cites W2061367467 @default.
- W2058374433 cites W2065285374 @default.
- W2058374433 cites W2072128091 @default.
- W2058374433 cites W2085197940 @default.
- W2058374433 cites W2086061041 @default.
- W2058374433 cites W2089753996 @default.
- W2058374433 cites W2101037339 @default.
- W2058374433 cites W2105088175 @default.
- W2058374433 cites W2111622605 @default.
- W2058374433 cites W2112327424 @default.
- W2058374433 cites W2112387151 @default.
- W2058374433 cites W2114998237 @default.
- W2058374433 cites W2118671972 @default.
- W2058374433 cites W2118769864 @default.
- W2058374433 cites W2123020552 @default.
- W2058374433 cites W2125947059 @default.
- W2058374433 cites W2127823872 @default.
- W2058374433 cites W2128021675 @default.
- W2058374433 cites W2128064256 @default.
- W2058374433 cites W2129269004 @default.
- W2058374433 cites W2143250882 @default.
- W2058374433 cites W2143901024 @default.
- W2058374433 cites W2154169469 @default.
- W2058374433 cites W2156422948 @default.
- W2058374433 cites W2162434225 @default.
- W2058374433 cites W2163592912 @default.
- W2058374433 cites W2170362706 @default.
- W2058374433 cites W2171078630 @default.
- W2058374433 cites W4294352168 @default.
- W2058374433 doi "https://doi.org/10.1158/0008-5472.can-09-2505" @default.
- W2058374433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2840073" @default.
- W2058374433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20197461" @default.
- W2058374433 hasPublicationYear "2010" @default.
- W2058374433 type Work @default.
- W2058374433 sameAs 2058374433 @default.
- W2058374433 citedByCount "188" @default.
- W2058374433 countsByYear W20583744332012 @default.
- W2058374433 countsByYear W20583744332013 @default.
- W2058374433 countsByYear W20583744332014 @default.
- W2058374433 countsByYear W20583744332015 @default.
- W2058374433 countsByYear W20583744332016 @default.
- W2058374433 countsByYear W20583744332017 @default.
- W2058374433 countsByYear W20583744332018 @default.
- W2058374433 countsByYear W20583744332019 @default.
- W2058374433 countsByYear W20583744332020 @default.
- W2058374433 countsByYear W20583744332021 @default.
- W2058374433 countsByYear W20583744332022 @default.
- W2058374433 countsByYear W20583744332023 @default.
- W2058374433 crossrefType "journal-article" @default.
- W2058374433 hasAuthorship W2058374433A5007648823 @default.
- W2058374433 hasAuthorship W2058374433A5043636220 @default.
- W2058374433 hasAuthorship W2058374433A5049546733 @default.
- W2058374433 hasBestOaLocation W20583744331 @default.
- W2058374433 hasConcept C104317684 @default.
- W2058374433 hasConcept C121608353 @default.
- W2058374433 hasConcept C127561419 @default.
- W2058374433 hasConcept C1491633281 @default.
- W2058374433 hasConcept C172512520 @default.
- W2058374433 hasConcept C2778227246 @default.
- W2058374433 hasConcept C2779256057 @default.
- W2058374433 hasConcept C2780932548 @default.
- W2058374433 hasConcept C28328180 @default.
- W2058374433 hasConcept C502942594 @default.
- W2058374433 hasConcept C54355233 @default.
- W2058374433 hasConcept C55427017 @default.
- W2058374433 hasConcept C55493867 @default.
- W2058374433 hasConcept C62478195 @default.
- W2058374433 hasConcept C86803240 @default.
- W2058374433 hasConcept C95444343 @default.
- W2058374433 hasConcept C96232424 @default.
- W2058374433 hasConceptScore W2058374433C104317684 @default.