FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058376859> ?p ?o ?g. }

• W2058376859 endingPage "142" @default.
• W2058376859 startingPage "125" @default.
• W2058376859 abstract "Summary Streptococcus pneumoniae serotype 3 strains are highly resistant to opsonophagocytosis due to recruitment of the complement inhibitor Factor H via Hic, a member of the pneumococcal surface protein C (PspC) family. In this study, we demonstrated that Hic also interacts with vitronectin, a fluid-phase regulator involved in haemostasis, angiogenesis, and the terminal complement cascade as well as a component of the extracellular matrix. Blocking of Hic by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In parallel, ectopic expression of Hic on the surface of Lactococcus lactis conferred binding to soluble and immobilised vitronectin as well as Factor H. Molecular analyses with truncated Hic fragments narrowed down the vitronectin-binding site to the central core of Hic (aa 151–201). This vitronectin-binding region is separate from that of Factor H, which binds to the N-terminus of Hic (aa 38–92). Binding of pneumococcal Hic was localised to the C-terminal heparin-binding domain (HBD3) of vitronectin. However, an N-terminal region to HBD3 was further involved in Hic-binding to immobilised vitronectin. Finally, vitronectin bound to Hic was functionally active and inhibited formation of the terminal complement complex. In conclusion, Hic interacts with vitronectin and simultaneously with Factor H, and both human proteins may contribute to colonisation and invasive disease caused by serotype 3 pneumococci." @default.
• W2058376859 created "2016-06-24" @default.
• W2058376859 creator A5005679859 @default.
• W2058376859 creator A5009914609 @default.
• W2058376859 creator A5048707669 @default.
• W2058376859 creator A5057961204 @default.
• W2058376859 creator A5065108689 @default.
• W2058376859 creator A5067381987 @default.
• W2058376859 creator A5078106788 @default.
• W2058376859 date "2015-01-01" @default.
• W2058376859 modified "2023-10-03" @default.
• W2058376859 title "Binding of vitronectin and Factor H to Hic contributes to immune evasion of Streptococcus pneumoniae serotype 3" @default.
• W2058376859 cites W1508637059 @default.
• W2058376859 cites W1541085566 @default.
• W2058376859 cites W1565685526 @default.
• W2058376859 cites W1569782548 @default.
• W2058376859 cites W1583880295 @default.
• W2058376859 cites W1748615915 @default.
• W2058376859 cites W1827417957 @default.
• W2058376859 cites W1862346143 @default.
• W2058376859 cites W1962890795 @default.
• W2058376859 cites W1966102221 @default.
• W2058376859 cites W1972180848 @default.
• W2058376859 cites W1973339314 @default.
• W2058376859 cites W2006044459 @default.
• W2058376859 cites W2020363725 @default.
• W2058376859 cites W2023964275 @default.
• W2058376859 cites W2035575053 @default.
• W2058376859 cites W2044629043 @default.
• W2058376859 cites W2045840718 @default.
• W2058376859 cites W2051279034 @default.
• W2058376859 cites W2052759282 @default.
• W2058376859 cites W2055079545 @default.
• W2058376859 cites W2061988541 @default.
• W2058376859 cites W2065650297 @default.
• W2058376859 cites W2066663106 @default.
• W2058376859 cites W2067365576 @default.
• W2058376859 cites W2072023518 @default.
• W2058376859 cites W2078235464 @default.
• W2058376859 cites W2085285106 @default.
• W2058376859 cites W2086491276 @default.
• W2058376859 cites W2093093385 @default.
• W2058376859 cites W2097180636 @default.
• W2058376859 cites W2102681875 @default.
• W2058376859 cites W2114379764 @default.
• W2058376859 cites W2116308765 @default.
• W2058376859 cites W2125506133 @default.
• W2058376859 cites W2127007459 @default.
• W2058376859 cites W2132323169 @default.
• W2058376859 cites W2132644314 @default.
• W2058376859 cites W2139951580 @default.
• W2058376859 cites W2140479313 @default.
• W2058376859 cites W2148619574 @default.
• W2058376859 cites W2152887455 @default.
• W2058376859 cites W2159726435 @default.
• W2058376859 cites W2162339585 @default.
• W2058376859 cites W2164536445 @default.
• W2058376859 cites W2167221249 @default.
• W2058376859 cites W2167809238 @default.
• W2058376859 cites W2168613507 @default.
• W2058376859 cites W2168998399 @default.
• W2058376859 cites W2171827842 @default.
• W2058376859 cites W2177719047 @default.
• W2058376859 cites W2318628477 @default.
• W2058376859 cites W2319123171 @default.
• W2058376859 cites W2326523156 @default.
• W2058376859 cites W28876791 @default.
• W2058376859 doi "https://doi.org/10.1160/th14-06-0561" @default.
• W2058376859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25181963" @default.
• W2058376859 hasPublicationYear "2015" @default.
• W2058376859 type Work @default.
• W2058376859 sameAs 2058376859 @default.
• W2058376859 citedByCount "23" @default.
• W2058376859 countsByYear W20583768592015 @default.
• W2058376859 countsByYear W20583768592016 @default.
• W2058376859 countsByYear W20583768592017 @default.
• W2058376859 countsByYear W20583768592018 @default.
• W2058376859 countsByYear W20583768592019 @default.
• W2058376859 countsByYear W20583768592020 @default.
• W2058376859 countsByYear W20583768592021 @default.
• W2058376859 countsByYear W20583768592022 @default.
• W2058376859 crossrefType "journal-article" @default.
• W2058376859 hasAuthorship W2058376859A5005679859 @default.
• W2058376859 hasAuthorship W2058376859A5009914609 @default.
• W2058376859 hasAuthorship W2058376859A5048707669 @default.
• W2058376859 hasAuthorship W2058376859A5057961204 @default.
• W2058376859 hasAuthorship W2058376859A5065108689 @default.
• W2058376859 hasAuthorship W2058376859A5067381987 @default.
• W2058376859 hasAuthorship W2058376859A5078106788 @default.
• W2058376859 hasBestOaLocation W20583768592 @default.
• W2058376859 hasConcept C104317684 @default.
• W2058376859 hasConcept C107824862 @default.
• W2058376859 hasConcept C111684460 @default.
• W2058376859 hasConcept C14356644 @default.
• W2058376859 hasConcept C153911025 @default.
• W2058376859 hasConcept C159654299 @default.
• W2058376859 hasConcept C164144092 @default.
• W2058376859 hasConcept C185592680 @default.

• next