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- W2058388670 abstract "We have recently shown that estrogen negatively modulates the hypotensive effect of clonidine (mixed α 2 -/I 1 -receptor agonist) in female rats and implicates the cardiovascular autonomic control in this interaction. The present study investigated whether this effect of estrogen involves interaction with α 2 - and/or I 1 -receptors. Changes evoked by a single intraperitoneal injection of rilmenidine (600 μg/kg) or α-methyldopa (100 mg/kg), selective I 1 - and α 2 -receptor agonists, respectively, in blood pressure, hemodynamic variability, and locomotor activity were assessed in radiotelemetered sham-operated and ovariectomized (Ovx) Sprague-Dawley female rats with or without 12-wk estrogen replacement. Three time domain indexes of hemodynamic variability were employed: the standard deviation of mean arterial pressure as a measure of blood pressure variability and the standard deviation of beat-to-beat intervals (SDRR) and the root mean square of successive differences in R-wave-to-R-wave intervals as measures of heart rate variability. In sham-operated rats, rilmenidine or α-methyldopa elicited similar hypotension that lasted at least 5 h and was associated with reductions in standard deviation of mean arterial pressure. SDRR was reduced only by α-methyldopa. Ovx significantly enhanced the hypotensive response to α-methyldopa, in contrast to no effect on rilmenidine hypotension. The enhanced α-methyldopa hypotension in Ovx rats was paralleled with further reduction in SDRR and a reduced locomotor activity. Estrogen replacement (17β-estradiol subcutaneous pellet, 14.2 μg/day, 12 wk) of Ovx rats restored the hemodynamic and locomotor effects of α-methyldopa to sham-operated levels. These findings suggest that estrogen downregulates α 2 - but not I 1 -receptor-mediated hypotension and highlight a role for the cardiac autonomic control in α-methyldopa-estrogen interaction." @default.
- W2058388670 created "2016-06-24" @default.
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- W2058388670 date "2004-10-01" @default.
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- W2058388670 title "Differential modulation by estrogen of α<sub>2</sub>-adrenergic and I<sub>1</sub>-imidazoline receptor-mediated hypotension in female rats" @default.
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- W2058388670 doi "https://doi.org/10.1152/japplphysiol.00401.2004" @default.
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