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- W2058398489 abstract "The cadherin superfamily is a diverse and multifunctional group of proteins with extensive representation across genomes of phylogenetically distant species that is involved in cell–cell communication and adhesion. The mosquito <em>Anopheles gambiae</em> is an emerging model organism for the study of innate immunity and host–pathogen interactions, where the malaria parasite induces a profound rearrangement of the actin cytoskeleton at critical stages of infection. We have used bioinformatics tools to retrieve present sequence knowledge about the complete repertoire of cadherins in <em>A. gambiae</em> and compared it to that of the fruit fly, <em>Drosophila melanogaster</em>. In <em>A. gambiae</em>, we have identified 43 genes coding for cadherin extracellular domains that were re-annotated to 38 genes and represent an expansion of this gene family in comparison to other invertebrate organisms. The majority of <em>Drosophila</em> cadherins show a 1 : 1 <em>Anopheles</em> orthologue, but we have observed a remarkable expansion in some groups in <em>A. gambiae</em>, such as N-cadherins, that were recently shown to have a role in the olfactory system of the fruit fly. <em>In vivo</em> dsRNA silencing of overrepresented genes in <em>A. gambiae</em> and other genes showing expression at critical tissues for parasite infection will likely advance our understanding of the problems of host preference and host𕢓pathogen interactions in this mosquito species." @default.
- W2058398489 created "2016-06-24" @default.
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- W2058398489 date "2005-01-01" @default.
- W2058398489 modified "2023-10-16" @default.
- W2058398489 title "The Cadherin Superfamily in Anopheles gambiae: a Comparative Study With Drosophila melanogaster" @default.
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- W2058398489 doi "https://doi.org/10.1002/cfg.473" @default.
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