FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058400226> ?p ?o ?g. }

• W2058400226 endingPage "1108" @default.
• W2058400226 startingPage "1099" @default.
• W2058400226 abstract "Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed when metastatic events have occurred. Cancer stem cells (CSCs) play an important role in tumor initiation, metastasis, chemoresistance and relapse. A growing number of studies have suggested that CSCs exist in a dynamic equilibrium with more differentiated cancer cells via a bi‑directional regeneration that is dependent on the environmental stimuli. In this investigation, we obtain, by using a selective medium, PDAC CSCs from five out of nine PDAC cell lines, endowed with different tumorsphere‑forming ability. PDAC CSCs were generally more resistant to the action of five anticancer drugs than parental cell lines and were characterized by an increased expression of EpCAM and CD44v6, typical stem cell surface markers, and a decreased expression of E‑cadherin, the main marker of the epithelial state. PDAC CSCs were able to re‑differentiate into parental cells once cultured in parental growth condition, as demonstrated by re‑acquisition of the epithelial morphology, the decreased expression levels of EpCAM and CD44v6 and the increased sensitivity to anticancer drugs. Finally, PDAC CSCs injected into nude mice developed a larger subcutaneous tumor mass and showed a higher metastatic activity compared to parental cells. The present study demonstrates the ability to obtain CSCs from several PDAC cell lines and that these cells are differentially resistant to various anticancer agents. This variability renders them a model of great importance to deeply understand pancreatic adenocarcinoma biology, to discover new biomarkers and to screen new therapeutic compounds." @default.
• W2058400226 created "2016-06-24" @default.
• W2058400226 creator A5003507376 @default.
• W2058400226 creator A5007177776 @default.
• W2058400226 creator A5014448714 @default.
• W2058400226 creator A5032293712 @default.
• W2058400226 creator A5037545172 @default.
• W2058400226 creator A5038228692 @default.
• W2058400226 creator A5040632094 @default.
• W2058400226 creator A5046301295 @default.
• W2058400226 creator A5049680516 @default.
• W2058400226 creator A5055628496 @default.
• W2058400226 creator A5067979740 @default.
• W2058400226 creator A5078769836 @default.
• W2058400226 creator A5087273761 @default.
• W2058400226 date "2014-12-12" @default.
• W2058400226 modified "2023-10-17" @default.
• W2058400226 title "Pancreatic ductal adenocarcinoma cell lines display a plastic ability to bi-directionally convert into cancer stem cells" @default.
• W2058400226 cites W1535298867 @default.
• W2058400226 cites W1547138419 @default.
• W2058400226 cites W1734170005 @default.
• W2058400226 cites W1965477746 @default.
• W2058400226 cites W1969204556 @default.
• W2058400226 cites W1974423029 @default.
• W2058400226 cites W1974889520 @default.
• W2058400226 cites W1999941999 @default.
• W2058400226 cites W2003941335 @default.
• W2058400226 cites W2009886857 @default.
• W2058400226 cites W2018385059 @default.
• W2058400226 cites W2019214567 @default.
• W2058400226 cites W2019264784 @default.
• W2058400226 cites W2037386039 @default.
• W2058400226 cites W2039825295 @default.
• W2058400226 cites W2042995204 @default.
• W2058400226 cites W2050300062 @default.
• W2058400226 cites W2056422677 @default.
• W2058400226 cites W2061876263 @default.
• W2058400226 cites W2062069198 @default.
• W2058400226 cites W2074998746 @default.
• W2058400226 cites W2078552560 @default.
• W2058400226 cites W2080511094 @default.
• W2058400226 cites W2082481019 @default.
• W2058400226 cites W2096638312 @default.
• W2058400226 cites W2097829773 @default.
• W2058400226 cites W2130552015 @default.
• W2058400226 cites W2131170195 @default.
• W2058400226 cites W2151948621 @default.
• W2058400226 cites W2162102296 @default.
• W2058400226 doi "https://doi.org/10.3892/ijo.2014.2796" @default.
• W2058400226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25502497" @default.
• W2058400226 hasPublicationYear "2014" @default.
• W2058400226 type Work @default.
• W2058400226 sameAs 2058400226 @default.
• W2058400226 citedByCount "43" @default.
• W2058400226 countsByYear W20584002262015 @default.
• W2058400226 countsByYear W20584002262016 @default.
• W2058400226 countsByYear W20584002262017 @default.
• W2058400226 countsByYear W20584002262018 @default.
• W2058400226 countsByYear W20584002262019 @default.
• W2058400226 countsByYear W20584002262020 @default.
• W2058400226 countsByYear W20584002262021 @default.
• W2058400226 countsByYear W20584002262022 @default.
• W2058400226 countsByYear W20584002262023 @default.
• W2058400226 crossrefType "journal-article" @default.
• W2058400226 hasAuthorship W2058400226A5003507376 @default.
• W2058400226 hasAuthorship W2058400226A5007177776 @default.
• W2058400226 hasAuthorship W2058400226A5014448714 @default.
• W2058400226 hasAuthorship W2058400226A5032293712 @default.
• W2058400226 hasAuthorship W2058400226A5037545172 @default.
• W2058400226 hasAuthorship W2058400226A5038228692 @default.
• W2058400226 hasAuthorship W2058400226A5040632094 @default.
• W2058400226 hasAuthorship W2058400226A5046301295 @default.
• W2058400226 hasAuthorship W2058400226A5049680516 @default.
• W2058400226 hasAuthorship W2058400226A5055628496 @default.
• W2058400226 hasAuthorship W2058400226A5067979740 @default.
• W2058400226 hasAuthorship W2058400226A5078769836 @default.
• W2058400226 hasAuthorship W2058400226A5087273761 @default.
• W2058400226 hasBestOaLocation W20584002261 @default.
• W2058400226 hasConcept C121608353 @default.
• W2058400226 hasConcept C136302470 @default.
• W2058400226 hasConcept C1491633281 @default.
• W2058400226 hasConcept C2778287671 @default.
• W2058400226 hasConcept C2779013556 @default.
• W2058400226 hasConcept C2780210213 @default.
• W2058400226 hasConcept C2781018059 @default.
• W2058400226 hasConcept C2781182431 @default.
• W2058400226 hasConcept C28328180 @default.
• W2058400226 hasConcept C29537977 @default.
• W2058400226 hasConcept C502942594 @default.
• W2058400226 hasConcept C54355233 @default.
• W2058400226 hasConcept C55427017 @default.
• W2058400226 hasConcept C67082663 @default.
• W2058400226 hasConcept C81885089 @default.
• W2058400226 hasConcept C86803240 @default.
• W2058400226 hasConcept C95444343 @default.
• W2058400226 hasConcept C96232424 @default.
• W2058400226 hasConceptScore W2058400226C121608353 @default.
• W2058400226 hasConceptScore W2058400226C136302470 @default.

• next