Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058403008> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2058403008 endingPage "802" @default.
- W2058403008 startingPage "799" @default.
- W2058403008 abstract "The protective effects of estrogen on the cardiovascular system are thought to be mediated, in part, by nitric oxide (NO). Estrogen also has protective effects on bone although the mechanisms of action have not been fully established. Since nitric oxide synthase (NOS) inhibitors have been found to abrogate the protective effect of estrogen on bone in ovariectomised rats, we studied the effects of 17beta-estradiol on NOS activity and NOS mRNA levels in cultured human osteoblast-like cells. 17beta-Estradiol stimulated NOS activity by approximately 2.0 fold and this effect was reversed by the calcium chelator, EGTA, and the NOS inhibitor, L-NMMA, implicating activation of a constitutive, calcium-dependent isoform. Further studies using RT/PCR indicated that only the endothelial nitric oxide synthase (ecNOS) isoform was expressed and RNase protection assays showed that 17beta-Estradiol treatment resulted in a 2.2 fold increase in ecNOS mRNA levels. These findings suggest that estrogen stimulates NOS activity in osteoblastic cells by activation of the ecNOS pathway, and taken together with previous data, is consistent with the possibility that NO may act as a mediator of estrogen actions on bone." @default.
- W2058403008 created "2016-06-24" @default.
- W2058403008 creator A5036667571 @default.
- W2058403008 creator A5082848146 @default.
- W2058403008 date "1998-02-01" @default.
- W2058403008 modified "2023-10-17" @default.
- W2058403008 title "Estrogen Upregulates Endothelial Constitutive Nitric Oxide Synthase Expression in Human Osteoblast-Like Cells" @default.
- W2058403008 doi "https://doi.org/10.1210/endo.139.2.5910" @default.
- W2058403008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9449657" @default.
- W2058403008 hasPublicationYear "1998" @default.
- W2058403008 type Work @default.
- W2058403008 sameAs 2058403008 @default.
- W2058403008 citedByCount "83" @default.
- W2058403008 countsByYear W20584030082012 @default.
- W2058403008 countsByYear W20584030082013 @default.
- W2058403008 countsByYear W20584030082014 @default.
- W2058403008 countsByYear W20584030082015 @default.
- W2058403008 countsByYear W20584030082018 @default.
- W2058403008 countsByYear W20584030082019 @default.
- W2058403008 countsByYear W20584030082020 @default.
- W2058403008 countsByYear W20584030082021 @default.
- W2058403008 countsByYear W20584030082022 @default.
- W2058403008 crossrefType "journal-article" @default.
- W2058403008 hasAuthorship W2058403008A5036667571 @default.
- W2058403008 hasAuthorship W2058403008A5082848146 @default.
- W2058403008 hasBestOaLocation W20584030081 @default.
- W2058403008 hasConcept C126322002 @default.
- W2058403008 hasConcept C134018914 @default.
- W2058403008 hasConcept C185592680 @default.
- W2058403008 hasConcept C202751555 @default.
- W2058403008 hasConcept C2776992346 @default.
- W2058403008 hasConcept C2777164284 @default.
- W2058403008 hasConcept C2777622882 @default.
- W2058403008 hasConcept C2778260815 @default.
- W2058403008 hasConcept C2778326061 @default.
- W2058403008 hasConcept C2908688039 @default.
- W2058403008 hasConcept C519581460 @default.
- W2058403008 hasConcept C55493867 @default.
- W2058403008 hasConcept C71924100 @default.
- W2058403008 hasConcept C86803240 @default.
- W2058403008 hasConceptScore W2058403008C126322002 @default.
- W2058403008 hasConceptScore W2058403008C134018914 @default.
- W2058403008 hasConceptScore W2058403008C185592680 @default.
- W2058403008 hasConceptScore W2058403008C202751555 @default.
- W2058403008 hasConceptScore W2058403008C2776992346 @default.
- W2058403008 hasConceptScore W2058403008C2777164284 @default.
- W2058403008 hasConceptScore W2058403008C2777622882 @default.
- W2058403008 hasConceptScore W2058403008C2778260815 @default.
- W2058403008 hasConceptScore W2058403008C2778326061 @default.
- W2058403008 hasConceptScore W2058403008C2908688039 @default.
- W2058403008 hasConceptScore W2058403008C519581460 @default.
- W2058403008 hasConceptScore W2058403008C55493867 @default.
- W2058403008 hasConceptScore W2058403008C71924100 @default.
- W2058403008 hasConceptScore W2058403008C86803240 @default.
- W2058403008 hasIssue "2" @default.
- W2058403008 hasLocation W20584030081 @default.
- W2058403008 hasLocation W20584030082 @default.
- W2058403008 hasOpenAccess W2058403008 @default.
- W2058403008 hasPrimaryLocation W20584030081 @default.
- W2058403008 hasRelatedWork W1196822169 @default.
- W2058403008 hasRelatedWork W1903672112 @default.
- W2058403008 hasRelatedWork W2003538399 @default.
- W2058403008 hasRelatedWork W2021330452 @default.
- W2058403008 hasRelatedWork W2036533624 @default.
- W2058403008 hasRelatedWork W2058403008 @default.
- W2058403008 hasRelatedWork W2061561342 @default.
- W2058403008 hasRelatedWork W2062593997 @default.
- W2058403008 hasRelatedWork W2114204950 @default.
- W2058403008 hasRelatedWork W2170387219 @default.
- W2058403008 hasVolume "139" @default.
- W2058403008 isParatext "false" @default.
- W2058403008 isRetracted "false" @default.
- W2058403008 magId "2058403008" @default.
- W2058403008 workType "article" @default.