FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058421409> ?p ?o ?g. }

• W2058421409 endingPage "355" @default.
• W2058421409 startingPage "348" @default.
• W2058421409 abstract "Objective. Resistance to cisplatin-centered chemotherapy is a major cause of treatment failure in human ovarian cancer. Whereas PTEN, a tumor suppressor gene product, is believed to promote apoptosis primarily via inactivation of the PI3K/Akt cell survival pathway, recent evidence suggests that PTEN may function independently of this pathway. Activation of p53 is a key determinant of sensitivity to cisplatin-induced apoptosis. Whether PTEN can facilitate cisplatin sensitivity, and this involves the activation of p53, remains unclear. In this study, we determined whether and how PTEN over-expression sensitizes ovarian cancer cells to CDDP-induced apoptosis. Methods and results. Using pairs of chemosensitive and chemoresistant ovarian cancer cell lines (OV20028 vs. C13* and A2780-s vs. A2780-cp) as an in vitro model, we have examined the influence of PTEN over-expression in regulation of cisplatin-induced apoptosis. Apoptosis was assessed morphologically by Hoechst staining and confirmed by the detection of cleaved products of caspase-3 and PARP by Western blot. Over-expression of PTEN by PTEN cDNA transfection up-regulates p53 content and increases the sensitivity of chemoresistant cells to cisplatin-induced apoptosis without detectable changes in the levels of phosphorylated Akt and FKHR as well as FasL mRNA abundance as determined by Western blot and RT-PCR, respectively. PTEN-mediated chemosensitization was attenuated by p53 down-regulation by siRNA in C13*, a chemoresistant wild-type p53 cell. Moreover, PTEN over-expression failed to sensitize the chemoresistant p53 mutant ovarian cancer cell line A2780-cp to cisplatin-induced apoptosis, unless wild-type p53 was reconstituted by adenoviral p53 infection. Conclusion. Taken together, these data suggest that PTEN over-expression may represent a novel therapeutic approach for chemoresistant human ovarian cancer and that this may involve a p53-mediated apoptotic cascade independent of the PI3K/Akt pathway." @default.
• W2058421409 created "2016-06-24" @default.
• W2058421409 creator A5013170437 @default.
• W2058421409 creator A5049692154 @default.
• W2058421409 creator A5077613223 @default.
• W2058421409 creator A5082084084 @default.
• W2058421409 date "2006-08-01" @default.
• W2058421409 modified "2023-10-16" @default.
• W2058421409 title "Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner" @default.
• W2058421409 cites W1500729563 @default.
• W2058421409 cites W1625966995 @default.
• W2058421409 cites W1939083266 @default.
• W2058421409 cites W1967421034 @default.
• W2058421409 cites W1972239225 @default.
• W2058421409 cites W1981219604 @default.
• W2058421409 cites W1983845790 @default.
• W2058421409 cites W1984418041 @default.
• W2058421409 cites W1991494214 @default.
• W2058421409 cites W1999060066 @default.
• W2058421409 cites W2006422601 @default.
• W2058421409 cites W2022416092 @default.
• W2058421409 cites W2024306318 @default.
• W2058421409 cites W2027811142 @default.
• W2058421409 cites W2030573603 @default.
• W2058421409 cites W2031247754 @default.
• W2058421409 cites W2067751798 @default.
• W2058421409 cites W2068427129 @default.
• W2058421409 cites W2068912983 @default.
• W2058421409 cites W2072098931 @default.
• W2058421409 cites W2082575834 @default.
• W2058421409 cites W2094068658 @default.
• W2058421409 cites W2108640797 @default.
• W2058421409 cites W2111125738 @default.
• W2058421409 cites W2132279561 @default.
• W2058421409 cites W2135838271 @default.
• W2058421409 cites W2137035181 @default.
• W2058421409 cites W2147282943 @default.
• W2058421409 cites W2159550051 @default.
• W2058421409 cites W2161810908 @default.
• W2058421409 cites W2164032619 @default.
• W2058421409 cites W2164277862 @default.
• W2058421409 cites W4249022746 @default.
• W2058421409 cites W4379340656 @default.
• W2058421409 doi "https://doi.org/10.1016/j.ygyno.2005.12.033" @default.
• W2058421409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16545436" @default.
• W2058421409 hasPublicationYear "2006" @default.
• W2058421409 type Work @default.
• W2058421409 sameAs 2058421409 @default.
• W2058421409 citedByCount "91" @default.
• W2058421409 countsByYear W20584214092012 @default.
• W2058421409 countsByYear W20584214092013 @default.
• W2058421409 countsByYear W20584214092014 @default.
• W2058421409 countsByYear W20584214092015 @default.
• W2058421409 countsByYear W20584214092016 @default.
• W2058421409 countsByYear W20584214092017 @default.
• W2058421409 countsByYear W20584214092018 @default.
• W2058421409 countsByYear W20584214092019 @default.
• W2058421409 countsByYear W20584214092020 @default.
• W2058421409 countsByYear W20584214092021 @default.
• W2058421409 countsByYear W20584214092022 @default.
• W2058421409 countsByYear W20584214092023 @default.
• W2058421409 crossrefType "journal-article" @default.
• W2058421409 hasAuthorship W2058421409A5013170437 @default.
• W2058421409 hasAuthorship W2058421409A5049692154 @default.
• W2058421409 hasAuthorship W2058421409A5077613223 @default.
• W2058421409 hasAuthorship W2058421409A5082084084 @default.
• W2058421409 hasConcept C104317684 @default.
• W2058421409 hasConcept C121608353 @default.
• W2058421409 hasConcept C126322002 @default.
• W2058421409 hasConcept C190283241 @default.
• W2058421409 hasConcept C2776415932 @default.
• W2058421409 hasConcept C2776694085 @default.
• W2058421409 hasConcept C2777609662 @default.
• W2058421409 hasConcept C2778239845 @default.
• W2058421409 hasConcept C2778264664 @default.
• W2058421409 hasConcept C2780427987 @default.
• W2058421409 hasConcept C502942594 @default.
• W2058421409 hasConcept C54009773 @default.
• W2058421409 hasConcept C54355233 @default.
• W2058421409 hasConcept C55493867 @default.
• W2058421409 hasConcept C555283112 @default.
• W2058421409 hasConcept C71924100 @default.
• W2058421409 hasConcept C75217442 @default.
• W2058421409 hasConcept C81885089 @default.
• W2058421409 hasConcept C86554907 @default.
• W2058421409 hasConcept C86803240 @default.
• W2058421409 hasConceptScore W2058421409C104317684 @default.
• W2058421409 hasConceptScore W2058421409C121608353 @default.
• W2058421409 hasConceptScore W2058421409C126322002 @default.
• W2058421409 hasConceptScore W2058421409C190283241 @default.
• W2058421409 hasConceptScore W2058421409C2776415932 @default.
• W2058421409 hasConceptScore W2058421409C2776694085 @default.
• W2058421409 hasConceptScore W2058421409C2777609662 @default.
• W2058421409 hasConceptScore W2058421409C2778239845 @default.
• W2058421409 hasConceptScore W2058421409C2778264664 @default.
• W2058421409 hasConceptScore W2058421409C2780427987 @default.
• W2058421409 hasConceptScore W2058421409C502942594 @default.
• W2058421409 hasConceptScore W2058421409C54009773 @default.

• next