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- W2058428642 abstract "Four monoclonal antisera-identifying antigens with the identical tissue distribution and molecular weight of previously described Ia-like antigens were characterized. Two of these antisera, I-1 and I-2, identified antigens expressed on the HLA-D/DR positive cells from all HLA heterozygous individuals. Further characterization on homozygous typing cells (HTC's) demonstrated that I-2 was not reactive with most Dw7 and Dw11 HTC's. Monoclonal antisera, termed 1-LR1 and 1-LR2, defined polymorphic Ia-like antigens that demonstrated restricted expression of cells from HLA heterozygous individuals. Antigen I-LR1 was expressed on cells from 60% of HLA heterozygous and its reactivity with HTC's did not conform to any previously described monotypic or supertypic HLA-D/DR pattern. In contrast, I-LR2 was expressed on 40% of HLA heterozygotes and identified only HLA-DR3, 5, and 6 HTC's. Studies of families with HLA recombinants permitted the demonstration that the 1-LR1 and 1-LR2 antigens are tightly linked to the HLA-D/DR locus. These experiments permit the direct demonstration by immunoprecipitation, linkage studies, and MHC recombinant families that the p29,34 complex in man is closely linked to or is within the HLA-D/DR locus. These studies suggest that the human Ia-like antigens are more heterogenous than previously demonstrated and that monoclonal antisera will be useful in further defining the structural, genetic, and functional characteristics of these molecules." @default.
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- W2058428642 date "1981-02-01" @default.
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- W2058428642 title "Monoclonal antibodies defining serologically distinct HLA-D/DR related Ia-like antigens in man" @default.
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- W2058428642 doi "https://doi.org/10.1016/0198-8859(81)90009-4" @default.
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