FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058429572> ?p ?o ?g. }

• W2058429572 endingPage "1991" @default.
• W2058429572 startingPage "1985" @default.
• W2058429572 abstract "Rats of the Wistar Furth (WF) strain have hereditary macrothrombocytopenia (large mean platelet volume [MPV] with increased platelet size heterogeneity and reduced platelet count). Ultrastructural studies suggest that this anomaly results from erratic subdivision of megakaryocyte cytoplasm into platelets. In this study, we have examined protein profiles of platelets of WF rats for biochemical abnormalities associated with this anomaly. Marked decreases in protein bands with an Mr of 185, 57, 53, 16, 13, and 8 kd were observed in one-dimensional reduced SDS-PAGE gels in WF platelets compared with platelets of Wistar, Long Evans, and Sprague-Dawley rats. These proteins were released into the supernatant when washed platelets were treated with thrombin suggesting that they were alpha-granule proteins. These abnormalities were not present in offspring of crosses between Wistar Furth and Wistar rats; however, they were present in platelets of offspring with large MPV derived from backcrosses of (WF X Wistar) F1 males to WF females, but not in backcross offspring with normal platelet size. Immunoblotting confirmed decreased levels of thrombospondin, fibrinogen, and platelet factor 4 in WF platelets. Electron microscopic examination revealed that platelet alpha granules were usually smaller in Wistar Furth than in Wistar rats. In addition, immunogold electron microscopy demonstrated that the surface connected canalicular system of the large Wistar Furth platelets, contained dense material composed of alpha-granule proteins, not present in Wistar platelets. From these results, we conclude that the Wistar Furth rat platelet phenotype of large mean platelet volume and decreased levels of alpha-granule proteins represents an animal model resembling gray platelet syndrome. The autosomal recessive pattern of inheritance of the large MPV phenotype and platelet alpha-granule protein deficiencies suggests that a component common to both formation of platelet alpha granules, and subdivision of megakaryocyte cytoplasm into platelets, is quantitatively or qualitatively abnormal in Wistar Furth rat megakaryocytes and platelets." @default.
• W2058429572 created "2016-06-24" @default.
• W2058429572 creator A5025168797 @default.
• W2058429572 creator A5044271318 @default.
• W2058429572 creator A5064956146 @default.
• W2058429572 creator A5068100566 @default.
• W2058429572 creator A5087637417 @default.
• W2058429572 date "1991-06-01" @default.
• W2058429572 modified "2023-09-25" @default.
• W2058429572 title "Platelets of the Wistar Furth rat have reduced levels of alpha-granule proteins. An animal model resembling gray platelet syndrome." @default.
• W2058429572 cites W104583716 @default.
• W2058429572 cites W136828725 @default.
• W2058429572 cites W1542255203 @default.
• W2058429572 cites W1568858788 @default.
• W2058429572 cites W1605902218 @default.
• W2058429572 cites W173776831 @default.
• W2058429572 cites W191818889 @default.
• W2058429572 cites W1939647304 @default.
• W2058429572 cites W1969330658 @default.
• W2058429572 cites W1972379192 @default.
• W2058429572 cites W1973086259 @default.
• W2058429572 cites W1973121107 @default.
• W2058429572 cites W1974146559 @default.
• W2058429572 cites W1978904514 @default.
• W2058429572 cites W1985330271 @default.
• W2058429572 cites W1990604147 @default.
• W2058429572 cites W1990988714 @default.
• W2058429572 cites W2003014314 @default.
• W2058429572 cites W2018289835 @default.
• W2058429572 cites W2019701873 @default.
• W2058429572 cites W2027762244 @default.
• W2058429572 cites W2029315544 @default.
• W2058429572 cites W2047670417 @default.
• W2058429572 cites W2061891312 @default.
• W2058429572 cites W2065482230 @default.
• W2058429572 cites W2066436007 @default.
• W2058429572 cites W2067056664 @default.
• W2058429572 cites W2076530751 @default.
• W2058429572 cites W2080226094 @default.
• W2058429572 cites W2085727695 @default.
• W2058429572 cites W2090451941 @default.
• W2058429572 cites W2093612398 @default.
• W2058429572 cites W2100837269 @default.
• W2058429572 cites W2119361574 @default.
• W2058429572 cites W2150131232 @default.
• W2058429572 cites W2161749601 @default.
• W2058429572 cites W2285181697 @default.
• W2058429572 cites W2300090606 @default.
• W2058429572 cites W23262848 @default.
• W2058429572 cites W2396097722 @default.
• W2058429572 cites W2396807680 @default.
• W2058429572 cites W2401019411 @default.
• W2058429572 cites W2404987180 @default.
• W2058429572 cites W2410091668 @default.
• W2058429572 cites W2410638654 @default.
• W2058429572 cites W2410700463 @default.
• W2058429572 cites W2411288787 @default.
• W2058429572 cites W2411739438 @default.
• W2058429572 cites W2412745323 @default.
• W2058429572 cites W2412790931 @default.
• W2058429572 cites W2415315797 @default.
• W2058429572 cites W2416913462 @default.
• W2058429572 cites W2417951390 @default.
• W2058429572 cites W290209250 @default.
• W2058429572 cites W48196429 @default.
• W2058429572 cites W757754257 @default.
• W2058429572 cites W94129673 @default.
• W2058429572 doi "https://doi.org/10.1172/jci115226" @default.
• W2058429572 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/296952" @default.
• W2058429572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2040691" @default.
• W2058429572 hasPublicationYear "1991" @default.
• W2058429572 type Work @default.
• W2058429572 sameAs 2058429572 @default.
• W2058429572 citedByCount "23" @default.
• W2058429572 countsByYear W20584295722012 @default.
• W2058429572 countsByYear W20584295722023 @default.
• W2058429572 crossrefType "journal-article" @default.
• W2058429572 hasAuthorship W2058429572A5025168797 @default.
• W2058429572 hasAuthorship W2058429572A5044271318 @default.
• W2058429572 hasAuthorship W2058429572A5064956146 @default.
• W2058429572 hasAuthorship W2058429572A5068100566 @default.
• W2058429572 hasAuthorship W2058429572A5087637417 @default.
• W2058429572 hasBestOaLocation W20584295721 @default.
• W2058429572 hasConcept C109159458 @default.
• W2058429572 hasConcept C126322002 @default.
• W2058429572 hasConcept C134018914 @default.
• W2058429572 hasConcept C151730666 @default.
• W2058429572 hasConcept C153911025 @default.
• W2058429572 hasConcept C185592680 @default.
• W2058429572 hasConcept C190481736 @default.
• W2058429572 hasConcept C2779036427 @default.
• W2058429572 hasConcept C2779705218 @default.
• W2058429572 hasConcept C2781295650 @default.
• W2058429572 hasConcept C28328180 @default.
• W2058429572 hasConcept C3018697912 @default.
• W2058429572 hasConcept C49760210 @default.
• W2058429572 hasConcept C55493867 @default.
• W2058429572 hasConcept C71924100 @default.

• next