FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058432912> ?p ?o ?g. }

• W2058432912 endingPage "32" @default.
• W2058432912 startingPage "24" @default.
• W2058432912 abstract "Bacterial etiology of chronic rhinosinusitis (CRS) still remains controversial. Whereas Staphylococcus aureus enterotoxins have been detected in CRS, the impact of Staphylococcus epidermidis, a major commensal inhabitant of the nose, has not been studied. Among others, serine and cysteine proteases have been identified as factors of virulence in S. epidermidis.S. epidermidis was examined in tissue biopsies of 30 CRS patients (16 with nasal polyposis) using standard procedures. Primary human nasal epithelial cells from inferior nasal turbinates (HNECs), from nasal polyps (NPECs) and A549 airway epithelial cells were stimulated with S. epidermidis supernatants DSM20044 or ATCC35984 and the IL-8 and GRO-alpha response was quantified by ELISA. Protease-triggered chemokine responses and involvement of NF-kappaB were investigated by addition of protease or NF-kappaB inhibitors. Activation of NF-kappaB was demonstrated by quantitative DNA binding assay.S. epidermidis was the most frequently isolated bacteria in the majority of CRS patients. HNECs and NPECs revealed no different IL-6 and IL-8 synthesis following stimulation with DSM20044 or ATCC35984. Stimulation of HNECs and A549 cells with S. epidermidis supernatants resulted in increased IL-8 and GRO-alpha expression which could be suppressed by the serine protease inhibitor AEBSF and the NF-kappaB inhibitor BAY 11 but not by the cysteine protease inhibitor E64. Results obtained for A549 cells were similar to HNECs.S. epidermidis was present in the majority of CRS specimens. Proinflammatory impact of S. epidermidis supernatants on nasal epithelial cells was demonstrated by serine protease-triggered and NF-kappaB-dependent chemokine responses." @default.
• W2058432912 created "2016-06-24" @default.
• W2058432912 creator A5003204399 @default.
• W2058432912 creator A5004992841 @default.
• W2058432912 creator A5069309035 @default.
• W2058432912 creator A5069518872 @default.
• W2058432912 creator A5070963176 @default.
• W2058432912 date "2007-08-16" @default.
• W2058432912 modified "2023-09-23" @default.
• W2058432912 title "Proinflammatory Impact of <i>Staphylococcus epidermidis</i> on the Nasal Epithelium Quantified by IL-8 and GRO-α Responses in Primary Human Nasal Epithelial Cells" @default.
• W2058432912 cites W1619991575 @default.
• W2058432912 cites W1874248752 @default.
• W2058432912 cites W1964321174 @default.
• W2058432912 cites W1976740525 @default.
• W2058432912 cites W1977056120 @default.
• W2058432912 cites W1990028850 @default.
• W2058432912 cites W2001170007 @default.
• W2058432912 cites W2010237936 @default.
• W2058432912 cites W2010293266 @default.
• W2058432912 cites W2013462204 @default.
• W2058432912 cites W2018011543 @default.
• W2058432912 cites W2019304194 @default.
• W2058432912 cites W2086923787 @default.
• W2058432912 cites W2089272736 @default.
• W2058432912 cites W2095198954 @default.
• W2058432912 cites W2119780153 @default.
• W2058432912 cites W2121217719 @default.
• W2058432912 cites W2121923279 @default.
• W2058432912 cites W2129761445 @default.
• W2058432912 cites W2131868847 @default.
• W2058432912 cites W2135599949 @default.
• W2058432912 cites W2147657681 @default.
• W2058432912 cites W2150990827 @default.
• W2058432912 cites W2160914462 @default.
• W2058432912 cites W2166636576 @default.
• W2058432912 cites W2168515303 @default.
• W2058432912 doi "https://doi.org/10.1159/000107463" @default.
• W2058432912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17703097" @default.
• W2058432912 hasPublicationYear "2007" @default.
• W2058432912 type Work @default.
• W2058432912 sameAs 2058432912 @default.
• W2058432912 citedByCount "20" @default.
• W2058432912 countsByYear W20584329122013 @default.
• W2058432912 countsByYear W20584329122014 @default.
• W2058432912 countsByYear W20584329122015 @default.
• W2058432912 countsByYear W20584329122016 @default.
• W2058432912 countsByYear W20584329122017 @default.
• W2058432912 countsByYear W20584329122018 @default.
• W2058432912 countsByYear W20584329122020 @default.
• W2058432912 countsByYear W20584329122022 @default.
• W2058432912 crossrefType "journal-article" @default.
• W2058432912 hasAuthorship W2058432912A5003204399 @default.
• W2058432912 hasAuthorship W2058432912A5004992841 @default.
• W2058432912 hasAuthorship W2058432912A5069309035 @default.
• W2058432912 hasAuthorship W2058432912A5069518872 @default.
• W2058432912 hasAuthorship W2058432912A5070963176 @default.
• W2058432912 hasConcept C126322002 @default.
• W2058432912 hasConcept C13373296 @default.
• W2058432912 hasConcept C164027704 @default.
• W2058432912 hasConcept C181199279 @default.
• W2058432912 hasConcept C182220744 @default.
• W2058432912 hasConcept C203014093 @default.
• W2058432912 hasConcept C2776714187 @default.
• W2058432912 hasConcept C2776914184 @default.
• W2058432912 hasConcept C2777714996 @default.
• W2058432912 hasConcept C2777807008 @default.
• W2058432912 hasConcept C2777949923 @default.
• W2058432912 hasConcept C2778690821 @default.
• W2058432912 hasConcept C2779489039 @default.
• W2058432912 hasConcept C2781390199 @default.
• W2058432912 hasConcept C523546767 @default.
• W2058432912 hasConcept C54355233 @default.
• W2058432912 hasConcept C55493867 @default.
• W2058432912 hasConcept C59377437 @default.
• W2058432912 hasConcept C68324877 @default.
• W2058432912 hasConcept C71924100 @default.
• W2058432912 hasConcept C81729549 @default.
• W2058432912 hasConcept C86803240 @default.
• W2058432912 hasConcept C8891405 @default.
• W2058432912 hasConcept C89423630 @default.
• W2058432912 hasConceptScore W2058432912C126322002 @default.
• W2058432912 hasConceptScore W2058432912C13373296 @default.
• W2058432912 hasConceptScore W2058432912C164027704 @default.
• W2058432912 hasConceptScore W2058432912C181199279 @default.
• W2058432912 hasConceptScore W2058432912C182220744 @default.
• W2058432912 hasConceptScore W2058432912C203014093 @default.
• W2058432912 hasConceptScore W2058432912C2776714187 @default.
• W2058432912 hasConceptScore W2058432912C2776914184 @default.
• W2058432912 hasConceptScore W2058432912C2777714996 @default.
• W2058432912 hasConceptScore W2058432912C2777807008 @default.
• W2058432912 hasConceptScore W2058432912C2777949923 @default.
• W2058432912 hasConceptScore W2058432912C2778690821 @default.
• W2058432912 hasConceptScore W2058432912C2779489039 @default.
• W2058432912 hasConceptScore W2058432912C2781390199 @default.
• W2058432912 hasConceptScore W2058432912C523546767 @default.
• W2058432912 hasConceptScore W2058432912C54355233 @default.
• W2058432912 hasConceptScore W2058432912C55493867 @default.
• W2058432912 hasConceptScore W2058432912C59377437 @default.

• next