FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058432955> ?p ?o ?g. }

• W2058432955 abstract "There is no established noninvasive or invasive diagnostic imaging modality at present that can serve as a ‘gold standard’ or “benchmark” for the detection of the venous anomalies, indicative of chronic cerebrospinal venous insufficiency (CCSVI). We investigated the sensitivity and specificity of 2 invasive vs. 2 noninvasive imaging techniques for the detection of extracranial venous anomalies in the internal jugular veins (IJVs) and azygos vein/vertebral veins (VVs) in patients with multiple sclerosis (MS). The data for this multimodal imaging comparison pilot study was collected in phase 2 of the “Prospective Randomized Endovascular therapy in Multiple Sclerosis” (PREMiSe) study using standardized imaging techniques. Thirty MS subjects were screened initially with Doppler sonography (DS), out of which 10 did not fulfill noninvasive screening procedure requirements on DS that consisted of ≥2 venous hemodynamic extracranial criteria. Accordingly, 20 MS patients with relapsing MS were enrolled into the multimodal diagnostic imaging study. For magnetic resonance venography (MRV), IJVs abnormal findings were considered absent or pinpoint flow, whereas abnormal VVs flow was classified as absent. Abnormalities of the VVs were determined only using non-invasive testing. Catheter venography (CV) was considered abnormal when ≥50% lumen restriction was detected, while intravascular ultrasound (IVUS) was considered abnormal when ≥50% restriction of the lumen or intra-luminal defects or reduced pulsatility was found. Non-invasive and invasive imaging modality comparisons between left, right and total IJVs and between the VVs and azygos vein were performed. Because there is no reliable way of non-invasively assessing the azygos vein, the VVs abnormalities detected by the non-invasive testing were compared to the azygos abnormalities detected by the invasive testing. All image modalities were analyzed in a blinded manner by more than one viewer, upon which consensus was reached. The sensitivity and specificity were calculated using contingency tables denoting the presence or absence of vein-specific abnormality findings between all imaging modalities used individually as the benchmark. The sensitivity of CV + IVUS was 68.4% for the right and 90% for the left IJV and 85.7% for the azygos vein/VVs, compared to venous anomalies detected on DS. Compared to the venous anomalies detected on MRV, the sensitivity of CV + IVUS was 71.4% in right and 100% in left IJVs and 100% in the azygos vein/VVs; however, the specificity was 38.5%, 38.9% and 11.8%, respectively. The sensitivity between the two invasive imaging techniques, used as benchmarks, ranged from 72.7% for the right IJV to 90% for the azygos vein but the IVUS showed a higher rate of venous anomalies than the CV. There was excellent correspondence between identifying collateral veins on MRV and CV. Noninvasive DS screening for the detection of venous anomalies indicative of CCSVI may be a reliable approach for identifying patients eligible for further multimodal invasive imaging testing of the IJVs. However, the noninvasive screening methods were inadequate to depict the total amount of azygos vein/VVs anomalies identified with invasive testing. This pilot study, with limited sample size, shows that both a non-invasive and invasive multimodal imaging diagnostic approach should be recommended to depict a range of extracranial venous anomalies indicative of CCSVI. However, lack of invasive testing on the study subjects whose results were negative on the DS screening and of healthy controls, limits further generalizibility of our findings. In addition, the findings from the 2 invasive techniques confirmed the existence of severe extracranial venous anomalies that significantly impaired normal blood outflow from the brain in this group of MS patients." @default.
• W2058432955 created "2016-06-24" @default.
• W2058432955 creator A5002097194 @default.
• W2058432955 creator A5005341542 @default.
• W2058432955 creator A5006794634 @default.
• W2058432955 creator A5011483739 @default.
• W2058432955 creator A5028101627 @default.
• W2058432955 creator A5037816826 @default.
• W2058432955 creator A5041550390 @default.
• W2058432955 creator A5043955065 @default.
• W2058432955 creator A5048566091 @default.
• W2058432955 creator A5073733099 @default.
• W2058432955 creator A5075596287 @default.
• W2058432955 creator A5079130521 @default.
• W2058432955 creator A5085028391 @default.
• W2058432955 date "2013-10-20" @default.
• W2058432955 modified "2023-10-17" @default.
• W2058432955 title "Multimodal noninvasive and invasive imaging of extracranial venous abnormalities indicative of CCSVI: Results of the PREMiSe pilot study" @default.
• W2058432955 cites W1991237568 @default.
• W2058432955 cites W1999115874 @default.
• W2058432955 cites W1999949972 @default.
• W2058432955 cites W2000974061 @default.
• W2058432955 cites W2008199441 @default.
• W2058432955 cites W2012213998 @default.
• W2058432955 cites W2026569587 @default.
• W2058432955 cites W2040164408 @default.
• W2058432955 cites W2047144532 @default.
• W2058432955 cites W2050885173 @default.
• W2058432955 cites W2053233225 @default.
• W2058432955 cites W2065038739 @default.
• W2058432955 cites W2066805681 @default.
• W2058432955 cites W2066987163 @default.
• W2058432955 cites W2087589796 @default.
• W2058432955 cites W2093388031 @default.
• W2058432955 cites W2094304732 @default.
• W2058432955 cites W2095433511 @default.
• W2058432955 cites W2107783338 @default.
• W2058432955 cites W2109104731 @default.
• W2058432955 cites W2109476682 @default.
• W2058432955 cites W2112165124 @default.
• W2058432955 cites W2112842014 @default.
• W2058432955 cites W2117059621 @default.
• W2058432955 cites W2121572293 @default.
• W2058432955 cites W2124480842 @default.
• W2058432955 cites W2126080719 @default.
• W2058432955 cites W2129175650 @default.
• W2058432955 cites W2130075988 @default.
• W2058432955 cites W2131682620 @default.
• W2058432955 cites W2132989814 @default.
• W2058432955 cites W2135403392 @default.
• W2058432955 cites W2143794884 @default.
• W2058432955 cites W2155030120 @default.
• W2058432955 cites W2164729544 @default.
• W2058432955 cites W2171829786 @default.
• W2058432955 cites W2319713275 @default.
• W2058432955 cites W4254694231 @default.
• W2058432955 doi "https://doi.org/10.1186/1471-2377-13-151" @default.
• W2058432955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4015359" @default.
• W2058432955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24139135" @default.
• W2058432955 hasPublicationYear "2013" @default.
• W2058432955 type Work @default.
• W2058432955 sameAs 2058432955 @default.
• W2058432955 citedByCount "16" @default.
• W2058432955 countsByYear W20584329552013 @default.
• W2058432955 countsByYear W20584329552014 @default.
• W2058432955 countsByYear W20584329552015 @default.
• W2058432955 countsByYear W20584329552016 @default.
• W2058432955 countsByYear W20584329552017 @default.
• W2058432955 countsByYear W20584329552019 @default.
• W2058432955 countsByYear W20584329552020 @default.
• W2058432955 countsByYear W20584329552021 @default.
• W2058432955 crossrefType "journal-article" @default.
• W2058432955 hasAuthorship W2058432955A5002097194 @default.
• W2058432955 hasAuthorship W2058432955A5005341542 @default.
• W2058432955 hasAuthorship W2058432955A5006794634 @default.
• W2058432955 hasAuthorship W2058432955A5011483739 @default.
• W2058432955 hasAuthorship W2058432955A5028101627 @default.
• W2058432955 hasAuthorship W2058432955A5037816826 @default.
• W2058432955 hasAuthorship W2058432955A5041550390 @default.
• W2058432955 hasAuthorship W2058432955A5043955065 @default.
• W2058432955 hasAuthorship W2058432955A5048566091 @default.
• W2058432955 hasAuthorship W2058432955A5073733099 @default.
• W2058432955 hasAuthorship W2058432955A5075596287 @default.
• W2058432955 hasAuthorship W2058432955A5079130521 @default.
• W2058432955 hasAuthorship W2058432955A5085028391 @default.
• W2058432955 hasBestOaLocation W20584329551 @default.
• W2058432955 hasConcept C118552586 @default.
• W2058432955 hasConcept C126322002 @default.
• W2058432955 hasConcept C126838900 @default.
• W2058432955 hasConcept C143409427 @default.
• W2058432955 hasConcept C2776250893 @default.
• W2058432955 hasConcept C2776931568 @default.
• W2058432955 hasConcept C2778269268 @default.
• W2058432955 hasConcept C2780640218 @default.
• W2058432955 hasConcept C2780868729 @default.
• W2058432955 hasConcept C40993552 @default.
• W2058432955 hasConcept C71924100 @default.
• W2058432955 hasConceptScore W2058432955C118552586 @default.
• W2058432955 hasConceptScore W2058432955C126322002 @default.
• W2058432955 hasConceptScore W2058432955C126838900 @default.

• next