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• W2058444182 startingPage "69" @default.
• W2058444182 abstract "Blister formation in skin and mucous membranes results from a loss of cell-cell or cell-matrix adhesion and is a common outcome of pathological events in a variety of conditions, including autoimmune and genetic diseases, viral and bacterial infections, or injury by physical and chemical factors. Autoantibodies against structural components maintaining cell-cell and cell-matrix adhesion induce tissue damage in autoimmune blistering diseases. Detection of these autoantibodies either tissue-bound or circulating in serum is essential to diagnose the autoimmune nature of disease. Various immunofluorescence methods as well as molecular immunoassays, including enzyme-linked immunosorbent assay and immunoblotting, belong to the modern diagnostic algorithms for these disorders. There is still a considerable need to increase awareness of the rare autoimmune blistering diseases, which often show a severe, chronic-relapsing course, among physicians and the public. This review article describes the immunopathological features of autoimmune bullous diseases and the molecular immunoassays currently available for their diagnosis and monitoring." @default.
• W2058444182 created "2016-06-24" @default.
• W2058444182 creator A5003409611 @default.
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• W2058444182 creator A5036446328 @default.
• W2058444182 creator A5045431309 @default.
• W2058444182 creator A5048808069 @default.
• W2058444182 date "2014-01-31" @default.
• W2058444182 modified "2023-10-05" @default.
• W2058444182 title "Molecular Diagnosis in Autoimmune Skin Blistering Conditions" @default.
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