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• W2058453956 abstract "Serotonin was linked by amidation to the carboxylic acid groups of a series of structurally diverse NSAIDs. The resulting NSAID-serotonin conjugates were tested in vitro for their ability to inhibit FAAH, TRPV1, and COX2. Ibuprofen-5-HT and Flurbiprofen-5-HT inhibited all three targets with approximately the same potency as N-arachidonoyl serotonin (AA-5-HT), while Fenoprofen-5-HT and Naproxen-5-HT showed activity as dual inhibitors of TRPV1 and COX2." @default.
• W2058453956 created "2016-06-24" @default.
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• W2058453956 date "2014-12-01" @default.
• W2058453956 modified "2023-09-25" @default.
• W2058453956 title "Inhibition of FAAH, TRPV1, and COX2 by NSAID–serotonin conjugates" @default.
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• W2058453956 doi "https://doi.org/10.1016/j.bmcl.2014.10.064" @default.
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