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• W2058454311 endingPage "10314" @default.
• W2058454311 startingPage "10307" @default.
• W2058454311 abstract "The distribution of bisphenol F (4,4‘-dihydroxydiphenyl-methane, BPF) was studied in female Sprague−Dawley rats. Pregnant and nonpregnant animals were gavaged with a single dose of 7 or 100 mg/kg [3H]BPF and were kept for 96 h in metabolic cages. The excretion of BPF residues occurred mainly in urine (43−54% of the administered dose), which was found to contain at least six different metabolites, and to a lesser extent in feces (15−20% of the administered dose). Sulfatase treatment and subsequent high-performance liquid chromatography analyses suggest that the major urinary metabolite (more than 50% of the radioactivity present in urine) is a sulfate conjugate of BPF. At 96 h, BPF residues were detectable in all tissues examined with the largest amounts in the liver (0.5% of the dose). In pregnant rats dosed at day 17 of gestation, BPF residues were detected in the uterus, placenta, amniotic fluid, and fetuses (0.9−1.3% of the administered dose). Large amounts of radioactivity (8−10% of the dose) were still located in the digestive tract lumen at the end of the study. After administration of a single oral dose of [3H]BPF, 46% of the distributed radioactivity was excreted in bile over a 6 h period. In rats, BPF and/or its metabolites very likely undergo enterohepatic cycling, which could be responsible for the relatively high amounts of residues still excreted 4 days after BPF administration. This bisphenol is efficiently absorbed and distributed to the reproductive tract in female rats, and its residues pass the placental barrier at a late stage of gestation in rats. Keywords: Bisphenol F; endocrine disruptor; residues; metabolism; distribution; rat; biotransformation; placental barrier; fetus" @default.
• W2058454311 created "2016-06-24" @default.
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• W2058454311 date "2006-12-01" @default.
• W2058454311 modified "2023-10-17" @default.
• W2058454311 title "Disposition and Metabolic Profiling of Bisphenol F in Pregnant and Nonpregnant Rats" @default.
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• W2058454311 doi "https://doi.org/10.1021/jf062250q" @default.
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