Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058461010> ?p ?o ?g. }
- W2058461010 endingPage "47" @default.
- W2058461010 startingPage "31" @default.
- W2058461010 abstract "In quality control of therapeutic proteins peptide mapping is used for confirmation of primary structure and detection of posttranslational modifications. The demands put on the experimental procedure are therefore different than in the case of determination of an unknown protein structure. It is here recognized that a peptide-mapping method for quality control of proteins should be inert (not induce or revert modifications), general, robust, and allow a high sample throughput. The steps prior to the separation of the generated peptides are identified as crucial for meeting these demands. This includes denaturation, reduction, alkylation, buffer exchange, solubilization, and digestion. A critical review of the literature regarding these steps is presented. Relevant options in all steps are experimentally evaluated. Novel approaches are developed for many of the steps. The result is a sample preparation procedure that essentially meets the stated demands." @default.
- W2058461010 created "2016-06-24" @default.
- W2058461010 creator A5000277150 @default.
- W2058461010 creator A5042353305 @default.
- W2058461010 date "1999-01-01" @default.
- W2058461010 modified "2023-10-14" @default.
- W2058461010 title "Sample Preparation for Peptide Mapping— A Pharmaceutical Quality-Control Perspective" @default.
- W2058461010 cites W1007761850 @default.
- W2058461010 cites W1147921248 @default.
- W2058461010 cites W1150202112 @default.
- W2058461010 cites W1154758160 @default.
- W2058461010 cites W1494066298 @default.
- W2058461010 cites W1531897377 @default.
- W2058461010 cites W1538623164 @default.
- W2058461010 cites W1550340517 @default.
- W2058461010 cites W1569457562 @default.
- W2058461010 cites W1571793851 @default.
- W2058461010 cites W1572618883 @default.
- W2058461010 cites W1587436271 @default.
- W2058461010 cites W1587862303 @default.
- W2058461010 cites W1588924604 @default.
- W2058461010 cites W1603440383 @default.
- W2058461010 cites W1636269886 @default.
- W2058461010 cites W167853497 @default.
- W2058461010 cites W1814739232 @default.
- W2058461010 cites W1833845085 @default.
- W2058461010 cites W192698215 @default.
- W2058461010 cites W1944789189 @default.
- W2058461010 cites W1966991787 @default.
- W2058461010 cites W1967582660 @default.
- W2058461010 cites W1974871974 @default.
- W2058461010 cites W1975733754 @default.
- W2058461010 cites W1976942152 @default.
- W2058461010 cites W1977540937 @default.
- W2058461010 cites W1983712352 @default.
- W2058461010 cites W1984062166 @default.
- W2058461010 cites W199231482 @default.
- W2058461010 cites W1993781774 @default.
- W2058461010 cites W1996784994 @default.
- W2058461010 cites W1996830342 @default.
- W2058461010 cites W1997480152 @default.
- W2058461010 cites W1998980349 @default.
- W2058461010 cites W2008212629 @default.
- W2058461010 cites W2009163884 @default.
- W2058461010 cites W2009227358 @default.
- W2058461010 cites W2013472041 @default.
- W2058461010 cites W2016497865 @default.
- W2058461010 cites W2017887308 @default.
- W2058461010 cites W2018040848 @default.
- W2058461010 cites W2023052786 @default.
- W2058461010 cites W2024558695 @default.
- W2058461010 cites W2025677254 @default.
- W2058461010 cites W2030392147 @default.
- W2058461010 cites W2033395581 @default.
- W2058461010 cites W2034634339 @default.
- W2058461010 cites W2036521193 @default.
- W2058461010 cites W2037508562 @default.
- W2058461010 cites W2042932646 @default.
- W2058461010 cites W2043030648 @default.
- W2058461010 cites W2043040669 @default.
- W2058461010 cites W2050523516 @default.
- W2058461010 cites W2053222344 @default.
- W2058461010 cites W2056499102 @default.
- W2058461010 cites W2059116744 @default.
- W2058461010 cites W2059640642 @default.
- W2058461010 cites W2063432215 @default.
- W2058461010 cites W2064159093 @default.
- W2058461010 cites W2067277094 @default.
- W2058461010 cites W2067290020 @default.
- W2058461010 cites W2073006935 @default.
- W2058461010 cites W2073300175 @default.
- W2058461010 cites W2073381828 @default.
- W2058461010 cites W2074308865 @default.
- W2058461010 cites W2076370909 @default.
- W2058461010 cites W2077031658 @default.
- W2058461010 cites W2078406990 @default.
- W2058461010 cites W2079629630 @default.
- W2058461010 cites W2081800439 @default.
- W2058461010 cites W2094409793 @default.
- W2058461010 cites W2094457928 @default.
- W2058461010 cites W2097474880 @default.
- W2058461010 cites W2101971141 @default.
- W2058461010 cites W2141236730 @default.
- W2058461010 cites W2150304477 @default.
- W2058461010 cites W2152013818 @default.
- W2058461010 cites W2212391707 @default.
- W2058461010 cites W2218032035 @default.
- W2058461010 cites W2316027456 @default.
- W2058461010 cites W2317012207 @default.
- W2058461010 cites W2402924449 @default.
- W2058461010 cites W263131988 @default.
- W2058461010 cites W2951895863 @default.
- W2058461010 cites W2952629490 @default.
- W2058461010 cites W3026079743 @default.
- W2058461010 cites W31465123 @default.
- W2058461010 cites W41629621 @default.
- W2058461010 cites W4248905202 @default.
- W2058461010 cites W4252115065 @default.