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• W2058462008 abstract "MicroRNAs (miRNAs) are a class of endogenous, non-coding small RNAs that negatively regulate gene expression at the post-transcriptional level. Several studies have provided evidence that abnormal expression of selected miRNAs is associated with the pathogenesis of cancer. As they can act as either oncogenes or tumor suppressors, miRNAs have been proposed as potential new therapeutic targets or tools for cancer therapy.This paper reviews a significant body of the experimental data collected to date which indicate that specific miRNA inhibition or replacement can successfully modify the proliferative and invasive properties of tumor cells. It discusses recent evidence that has also revealed a direct involvement of miRNAs in drug resistance, underlying an entirely new mechanism by which tumor cells may be refractory to the treatment with cytotoxic agents. Based on these findings, in the therapeutic setting, interference with cancer-specific miRNAs could be exploited not only to produce a direct anticancer effect but also to improve the response of tumor cells to conventional treatments.Overall, manipulation of miRNA functions, either by mimicking or inhibiting them, is emerging as a highly promising therapeutic strategy. However, before miRNA-based therapeutics enters the clinical armamentarium, important issues concerning specific delivery to cells/tissues of interest, safety as well as pharmacokinetic profiles needs to be addressed." @default.
• W2058462008 created "2016-06-24" @default.
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• W2058462008 date "2011-01-05" @default.
• W2058462008 modified "2023-09-30" @default.
• W2058462008 title "MicroRNAs as new therapeutic targets and tools in cancer" @default.
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• W2058462008 doi "https://doi.org/10.1517/14728222.2011.550878" @default.
• W2058462008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21208133" @default.
• W2058462008 hasPublicationYear "2011" @default.
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