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- W2058462303 abstract "Repetitive antigen stimulation by prime-boost vaccination or pathogen reencounter increases memory CD8+ T cell numbers, but the impact on memory CD8+ T cell differentiation is unknown. Here we showed that repetitive antigen stimulations induced accumulation of memory CD8+ T cells with uniform effector memory characteristics. However, genome-wide microarray analyses revealed that each additional antigen challenge resulted in the differential regulation of several hundred new genes in the ensuing memory CD8+ T cell populations and, therefore, in stepwise diversification of CD8+ T cell transcriptomes. Thus, primary and repeatedly stimulated (secondary, tertiary, and quaternary) memory CD8+ T cells differed substantially in their molecular signature while sharing expression of a small group of genes and biological pathways, which may constitute a core signature of memory differentiation. These results reveal the complex regulation of memory CD8+ T cell differentiation and identify potential new molecular targets to dissect the function of memory cells generated by repeated antigen stimulation." @default.
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- W2058462303 date "2010-07-01" @default.
- W2058462303 modified "2023-10-16" @default.
- W2058462303 title "Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation" @default.
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- W2058462303 doi "https://doi.org/10.1016/j.immuni.2010.06.014" @default.
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