FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058464043> ?p ?o ?g. }

• W2058464043 endingPage "295" @default.
• W2058464043 startingPage "295" @default.
• W2058464043 abstract "Chronic kidney disease (CKD) is a major public health problem worldwide with the estimated incidence growing by approximately 6% annually. There are striking ethnic differences in the prevalence of CKD such that, in the United States, African Americans have the highest prevalence of CKD, four times the incidence of end stage renal disease when compared to Americans of European ancestry suggestive of genetic predisposition. Diabetes mellitus, hypertension and human immunodeficiency virus (HIV) infection are the major causes of CKD. HIV-associated nephropathy (HIVAN) is an irreversible form of CKD with considerable morbidity and mortality and is present predominantly in people of African ancestry. The APOL1 G1 and G2 alleles were more strongly associated with the risk for CKD than the previously examined MYH9 E1 risk haplotype in individuals of African ancestry. A strong association was reported in HIVAN, suggesting that 50% of African Americans with two APOL1 risk alleles, if untreated, would develop HIVAN. However these two variants are not enough to cause disease. The prevailing belief is that modifying factors or second hits (including genetic hits) underlie the pathogenesis of kidney disease. This work reviews the history of genetic susceptibility of CKD and outlines current theories regarding the role for APOL1 in CKD in the HIV era." @default.
• W2058464043 created "2016-06-24" @default.
• W2058464043 creator A5018055193 @default.
• W2058464043 creator A5046734557 @default.
• W2058464043 creator A5055162088 @default.
• W2058464043 creator A5067532347 @default.
• W2058464043 date "2015-01-01" @default.
• W2058464043 modified "2023-10-18" @default.
• W2058464043 title "African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era" @default.
• W2058464043 cites W1607270055 @default.
• W2058464043 cites W1970070985 @default.
• W2058464043 cites W1974845434 @default.
• W2058464043 cites W1977165977 @default.
• W2058464043 cites W1981426400 @default.
• W2058464043 cites W1981743093 @default.
• W2058464043 cites W1983891915 @default.
• W2058464043 cites W1991375489 @default.
• W2058464043 cites W1994560902 @default.
• W2058464043 cites W1999030993 @default.
• W2058464043 cites W2001816360 @default.
• W2058464043 cites W2002359955 @default.
• W2058464043 cites W2005096683 @default.
• W2058464043 cites W2010807875 @default.
• W2058464043 cites W2018637683 @default.
• W2058464043 cites W2023694860 @default.
• W2058464043 cites W2024596225 @default.
• W2058464043 cites W2025026896 @default.
• W2058464043 cites W2030803259 @default.
• W2058464043 cites W2030923116 @default.
• W2058464043 cites W2042717820 @default.
• W2058464043 cites W2042888843 @default.
• W2058464043 cites W2047162910 @default.
• W2058464043 cites W2048441803 @default.
• W2058464043 cites W2049958520 @default.
• W2058464043 cites W2054891539 @default.
• W2058464043 cites W2058286579 @default.
• W2058464043 cites W2063711086 @default.
• W2058464043 cites W2065062655 @default.
• W2058464043 cites W2074402998 @default.
• W2058464043 cites W2079089319 @default.
• W2058464043 cites W2081539383 @default.
• W2058464043 cites W2082595989 @default.
• W2058464043 cites W2083333719 @default.
• W2058464043 cites W2100187907 @default.
• W2058464043 cites W2101633780 @default.
• W2058464043 cites W2102993652 @default.
• W2058464043 cites W2105658033 @default.
• W2058464043 cites W2107453992 @default.
• W2058464043 cites W2110595758 @default.
• W2058464043 cites W2110597957 @default.
• W2058464043 cites W2112311783 @default.
• W2058464043 cites W2114842781 @default.
• W2058464043 cites W2115650489 @default.
• W2058464043 cites W2121965895 @default.
• W2058464043 cites W2124641083 @default.
• W2058464043 cites W2125065061 @default.
• W2058464043 cites W2129316818 @default.
• W2058464043 cites W2135758545 @default.
• W2058464043 cites W2137096226 @default.
• W2058464043 cites W2144394963 @default.
• W2058464043 cites W2144535466 @default.
• W2058464043 cites W2145323130 @default.
• W2058464043 cites W2146597955 @default.
• W2058464043 cites W2148951685 @default.
• W2058464043 cites W2149616337 @default.
• W2058464043 cites W2150536115 @default.
• W2058464043 cites W2151877638 @default.
• W2058464043 cites W2152081598 @default.
• W2058464043 cites W2157421941 @default.
• W2058464043 cites W2158668074 @default.
• W2058464043 cites W2160095199 @default.
• W2058464043 cites W2160180886 @default.
• W2058464043 cites W2164061579 @default.
• W2058464043 cites W2165202423 @default.
• W2058464043 cites W2166585544 @default.
• W2058464043 cites W2167032249 @default.
• W2058464043 cites W2168074442 @default.
• W2058464043 cites W2169982370 @default.
• W2058464043 cites W2171777347 @default.
• W2058464043 cites W2171838950 @default.
• W2058464043 cites W2232736542 @default.
• W2058464043 cites W2322256416 @default.
• W2058464043 cites W1588048249 @default.
• W2058464043 doi "https://doi.org/10.5527/wjn.v4.i2.295" @default.
• W2058464043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4419140" @default.
• W2058464043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25949944" @default.
• W2058464043 hasPublicationYear "2015" @default.
• W2058464043 type Work @default.
• W2058464043 sameAs 2058464043 @default.
• W2058464043 citedByCount "24" @default.
• W2058464043 countsByYear W20584640432016 @default.
• W2058464043 countsByYear W20584640432017 @default.
• W2058464043 countsByYear W20584640432018 @default.
• W2058464043 countsByYear W20584640432019 @default.
• W2058464043 countsByYear W20584640432020 @default.
• W2058464043 countsByYear W20584640432021 @default.
• W2058464043 countsByYear W20584640432022 @default.
• W2058464043 countsByYear W20584640432023 @default.

• next