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• W2058473414 endingPage "1609" @default.
• W2058473414 startingPage "1607" @default.
• W2058473414 abstract "The PhoP/PhoQ two-component system is a master regulator of Salmonella pathogenicity. Here we report that induction of the PhoP/PhoQ system results in an initial surge of PhoP phosphorylation; the occupancy of target promoters by the PhoP protein; and the transcription of PhoP-activated genes, which then subsides to reach new steady-state levels. This surge in PhoP activity is due to PhoP positively activating its own transcription, because a strain constitutively expressing the PhoP protein attained steady-state levels of activation asymptotically, without the surge. The strain constitutively expressing the PhoP protein was attenuated for virulence in mice, demonstrating that the surge conferred by PhoP's positive feedback loop is necessary to jump-start Salmonella's virulence program." @default.
• W2058473414 created "2016-06-24" @default.
• W2058473414 creator A5026929908 @default.
• W2058473414 creator A5056341816 @default.
• W2058473414 creator A5063545607 @default.
• W2058473414 creator A5077752769 @default.
• W2058473414 date "2006-12-08" @default.
• W2058473414 modified "2023-10-01" @default.
• W2058473414 title "A Positive Feedback Loop Promotes Transcription Surge That Jump-Starts <i>Salmonella</i> Virulence Circuit" @default.
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• W2058473414 doi "https://doi.org/10.1126/science.1134930" @default.
• W2058473414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17158330" @default.
• W2058473414 hasPublicationYear "2006" @default.
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