Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058473422> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2058473422 abstract "The effect of PCP (1 mg/kg i.a.) on sympathetic and cardiovascular responses were studied in conscious rats and pithed intact and adrenalmedullectomized rats (MEDX). Also, we examined the effect of Phencyclidine (PCP) (3 mg/kg s.c.) on the uptake and disposition of [3H]norepinephrine [3H]NE in rat heart and plasma. In conscious rats, PCP significantly increased blood pressure (PB), heart rate (HR) and plasma catecholamine (CA). Sympathetic stimulation in pithed intact and MEDX rats elicited increases in PB, HR and plasma CA. Administration of PCP (1 mg/kg i.v.) prior to stimulation potentiated the pressor responses to stimulation in both intact and MEDX rats. The HR response to stimulation was reduced significantly in MEDX rats, suggesting it was largely related to epinephrine release. PCP (3 mg/kg s.c.) failed to alter significantly [3H]NE uptake by the heart after i.v. administration of labelled catecholamine nor prolong the presence in plasma of infused [3H]NE. These results suggest that, in conscious rats, PCP enhances sympathetic outflow from the central nervous system. The enhancement by PCP of stimulation-induced NE release in pithed rats suggests that the drug also has a presynaptic effect which enhances NE release from the sympathetic nerve endings. The enhancement by PCP of stimulation-induced increases in plasma NE cannot be attributed to differences in sympathetic outflow nor inhibition of uptake, suggesting a presynaptic effect leading to enhanced NE release." @default.
- W2058473422 created "2016-06-24" @default.
- W2058473422 creator A5042995179 @default.
- W2058473422 creator A5060247401 @default.
- W2058473422 date "1982-11-01" @default.
- W2058473422 modified "2023-09-25" @default.
- W2058473422 title "Effect of phencyclidine (PCP) on adrenergic responses to spinal cord stimulation in pithed rats" @default.
- W2058473422 cites W1840994181 @default.
- W2058473422 cites W1848034388 @default.
- W2058473422 cites W1967143599 @default.
- W2058473422 cites W1972817694 @default.
- W2058473422 cites W1994782432 @default.
- W2058473422 cites W1999084893 @default.
- W2058473422 cites W2010298174 @default.
- W2058473422 cites W2047098427 @default.
- W2058473422 cites W2051664368 @default.
- W2058473422 cites W2062796913 @default.
- W2058473422 cites W2083095953 @default.
- W2058473422 cites W2092771620 @default.
- W2058473422 cites W2211162354 @default.
- W2058473422 cites W2252568419 @default.
- W2058473422 cites W2288197714 @default.
- W2058473422 doi "https://doi.org/10.1016/0014-2999(82)90419-8" @default.
- W2058473422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7151861" @default.
- W2058473422 hasPublicationYear "1982" @default.
- W2058473422 type Work @default.
- W2058473422 sameAs 2058473422 @default.
- W2058473422 citedByCount "3" @default.
- W2058473422 crossrefType "journal-article" @default.
- W2058473422 hasAuthorship W2058473422A5042995179 @default.
- W2058473422 hasAuthorship W2058473422A5060247401 @default.
- W2058473422 hasConcept C126322002 @default.
- W2058473422 hasConcept C134018914 @default.
- W2058473422 hasConcept C158453852 @default.
- W2058473422 hasConcept C170493617 @default.
- W2058473422 hasConcept C185592680 @default.
- W2058473422 hasConcept C24998067 @default.
- W2058473422 hasConcept C2775859304 @default.
- W2058473422 hasConcept C2775894120 @default.
- W2058473422 hasConcept C2776394411 @default.
- W2058473422 hasConcept C2776533406 @default.
- W2058473422 hasConcept C2777953023 @default.
- W2058473422 hasConcept C2778514916 @default.
- W2058473422 hasConcept C2778851735 @default.
- W2058473422 hasConcept C513476851 @default.
- W2058473422 hasConcept C67018056 @default.
- W2058473422 hasConcept C71924100 @default.
- W2058473422 hasConcept C84393581 @default.
- W2058473422 hasConceptScore W2058473422C126322002 @default.
- W2058473422 hasConceptScore W2058473422C134018914 @default.
- W2058473422 hasConceptScore W2058473422C158453852 @default.
- W2058473422 hasConceptScore W2058473422C170493617 @default.
- W2058473422 hasConceptScore W2058473422C185592680 @default.
- W2058473422 hasConceptScore W2058473422C24998067 @default.
- W2058473422 hasConceptScore W2058473422C2775859304 @default.
- W2058473422 hasConceptScore W2058473422C2775894120 @default.
- W2058473422 hasConceptScore W2058473422C2776394411 @default.
- W2058473422 hasConceptScore W2058473422C2776533406 @default.
- W2058473422 hasConceptScore W2058473422C2777953023 @default.
- W2058473422 hasConceptScore W2058473422C2778514916 @default.
- W2058473422 hasConceptScore W2058473422C2778851735 @default.
- W2058473422 hasConceptScore W2058473422C513476851 @default.
- W2058473422 hasConceptScore W2058473422C67018056 @default.
- W2058473422 hasConceptScore W2058473422C71924100 @default.
- W2058473422 hasConceptScore W2058473422C84393581 @default.
- W2058473422 hasLocation W20584734221 @default.
- W2058473422 hasLocation W20584734222 @default.
- W2058473422 hasOpenAccess W2058473422 @default.
- W2058473422 hasPrimaryLocation W20584734221 @default.
- W2058473422 hasRelatedWork W134309881 @default.
- W2058473422 hasRelatedWork W1483304564 @default.
- W2058473422 hasRelatedWork W2019058625 @default.
- W2058473422 hasRelatedWork W2045045901 @default.
- W2058473422 hasRelatedWork W2048671465 @default.
- W2058473422 hasRelatedWork W2049456832 @default.
- W2058473422 hasRelatedWork W2057656522 @default.
- W2058473422 hasRelatedWork W2058473422 @default.
- W2058473422 hasRelatedWork W2060199686 @default.
- W2058473422 hasRelatedWork W2180683357 @default.
- W2058473422 isParatext "false" @default.
- W2058473422 isRetracted "false" @default.
- W2058473422 magId "2058473422" @default.
- W2058473422 workType "article" @default.