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- W2058476721 abstract "Multiple system atrophy with predominant parkinsonism (MSA-P) usually shows poor responsiveness to dopaminergic medications. We herein describe a patient with MSA-P who exhibited a good response to pramipexole but not to an ordinary dose of L-dopa. Positron emission tomography (PET) displayed severely impaired presynaptic dopaminergic availability and relatively preserved postsynaptic D2 receptor binding capacity. The pharmacokinetic analyses demonstrated relatively low bioavailability for L-dopa and adequate plasma levels of pramipexole, even at baseline, on a stable daily dose. The PET features and pharmacokinetic differences between L-dopa and pramipexole indicate the presence of unique therapeutic responses to dopaminergic medications in the patient." @default.
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- W2058476721 date "2013-01-01" @default.
- W2058476721 modified "2023-10-17" @default.
- W2058476721 title "Therapeutic Response to Pramipexole in a Patient with Multiple System Atrophy with Predominant Parkinsonism: Positron Emission Tomography and Pharmacokinetic Assessments" @default.
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- W2058476721 doi "https://doi.org/10.2169/internalmedicine.52.9442" @default.
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