FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058476722> ?p ?o ?g. }

• W2058476722 endingPage "19" @default.
• W2058476722 startingPage "19" @default.
• W2058476722 abstract "Selective estrogen receptor modulator (SERM) for the treatment of osteoporosis in postmenopausal women: focus on lasofoxifene Luigi Gennari, Daniela Merlotti, Ranuccio NutiDepartment of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Siena, ItalyAbstract: Selective estrogen receptor modulators (SERMs) represent a class with a growing number of compounds that act as either estrogen receptor agonists or antagonists in a tissuespecific manner. This article reviews lasofoxifene, a new-generation SERM that has completed phase III development for the prevention and treatment of osteoporosis in postmenopausal women. Consistent with preclinical observations, this new SERM demonstrated improved skeletal efficacy over raloxifene and at an oral dose of 0.5 mg/day was effective in the prevention of both vertebral and nonvertebral fractures in postmenopausal women with osteoporosis. At the same dosage, lasofoxifene treatment also reduced estrogen receptor-positive breast cancer risk and the occurrence of vaginal atrophy, but, like the other SERMs, was associated with hot flushes and an increased risk of venous thromboembolic events. With its increased efficacy on the prevention of nonvertebral fractures than current available SERMs and its positive effects on the vagina, this new compound may represent an alternative and cost-effective therapy for osteoporosis in postmenopausal women.Keywords: SERM, lasofoxifene, postmenopausal osteoporosis, fractures, bone density, menopause" @default.
• W2058476722 created "2016-06-24" @default.
• W2058476722 creator A5048078483 @default.
• W2058476722 date "2010-01-01" @default.
• W2058476722 modified "2023-10-12" @default.
• W2058476722 title "Selective estrogen receptor modulator (SERM) for the treatment of osteoporosis in postmenopausal women: focus on lasofoxifene" @default.
• W2058476722 cites W1514642917 @default.
• W2058476722 cites W1895595364 @default.
• W2058476722 cites W1966701899 @default.
• W2058476722 cites W1967648918 @default.
• W2058476722 cites W1968774230 @default.
• W2058476722 cites W1971909806 @default.
• W2058476722 cites W1977528094 @default.
• W2058476722 cites W1982942836 @default.
• W2058476722 cites W1989096197 @default.
• W2058476722 cites W1996155847 @default.
• W2058476722 cites W1996879302 @default.
• W2058476722 cites W1997883187 @default.
• W2058476722 cites W2004236425 @default.
• W2058476722 cites W2009325379 @default.
• W2058476722 cites W2010925208 @default.
• W2058476722 cites W2011460365 @default.
• W2058476722 cites W2013584301 @default.
• W2058476722 cites W2021749550 @default.
• W2058476722 cites W2032807957 @default.
• W2058476722 cites W2035195447 @default.
• W2058476722 cites W2039629869 @default.
• W2058476722 cites W2046776608 @default.
• W2058476722 cites W2048027227 @default.
• W2058476722 cites W2048813529 @default.
• W2058476722 cites W2049765534 @default.
• W2058476722 cites W2061023819 @default.
• W2058476722 cites W2061688221 @default.
• W2058476722 cites W2069811152 @default.
• W2058476722 cites W2076294660 @default.
• W2058476722 cites W2078885070 @default.
• W2058476722 cites W2087273432 @default.
• W2058476722 cites W2095636976 @default.
• W2058476722 cites W2101738855 @default.
• W2058476722 cites W2101833345 @default.
• W2058476722 cites W2102477226 @default.
• W2058476722 cites W2108063837 @default.
• W2058476722 cites W2110396808 @default.
• W2058476722 cites W2111650618 @default.
• W2058476722 cites W2112577860 @default.
• W2058476722 cites W2112629831 @default.
• W2058476722 cites W2113697838 @default.
• W2058476722 cites W2122053141 @default.
• W2058476722 cites W2126475875 @default.
• W2058476722 cites W2127692449 @default.
• W2058476722 cites W2128986278 @default.
• W2058476722 cites W2133507954 @default.
• W2058476722 cites W2134358473 @default.
• W2058476722 cites W2135686539 @default.
• W2058476722 cites W2143152245 @default.
• W2058476722 cites W2144238512 @default.
• W2058476722 cites W2146528087 @default.
• W2058476722 cites W2150539152 @default.
• W2058476722 cites W2151500090 @default.
• W2058476722 cites W2153538330 @default.
• W2058476722 cites W2160287478 @default.
• W2058476722 cites W2161546266 @default.
• W2058476722 cites W2163459122 @default.
• W2058476722 cites W2171759718 @default.
• W2058476722 cites W2484045037 @default.
• W2058476722 cites W2101112174 @default.
• W2058476722 doi "https://doi.org/10.2147/cia.s6083" @default.
• W2058476722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2817938" @default.
• W2058476722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20169039" @default.
• W2058476722 hasPublicationYear "2010" @default.
• W2058476722 type Work @default.
• W2058476722 sameAs 2058476722 @default.
• W2058476722 citedByCount "46" @default.
• W2058476722 countsByYear W20584767222012 @default.
• W2058476722 countsByYear W20584767222013 @default.
• W2058476722 countsByYear W20584767222014 @default.
• W2058476722 countsByYear W20584767222015 @default.
• W2058476722 countsByYear W20584767222016 @default.
• W2058476722 countsByYear W20584767222017 @default.
• W2058476722 countsByYear W20584767222018 @default.
• W2058476722 countsByYear W20584767222019 @default.
• W2058476722 countsByYear W20584767222020 @default.
• W2058476722 countsByYear W20584767222021 @default.
• W2058476722 countsByYear W20584767222022 @default.
• W2058476722 countsByYear W20584767222023 @default.
• W2058476722 crossrefType "journal-article" @default.
• W2058476722 hasAuthorship W2058476722A5048078483 @default.
• W2058476722 hasBestOaLocation W20584767221 @default.
• W2058476722 hasConcept C121608353 @default.
• W2058476722 hasConcept C126322002 @default.
• W2058476722 hasConcept C134018914 @default.
• W2058476722 hasConcept C2776541429 @default.
• W2058476722 hasConcept C2777176818 @default.
• W2058476722 hasConcept C2777944059 @default.
• W2058476722 hasConcept C2778562196 @default.
• W2058476722 hasConcept C2779889926 @default.
• W2058476722 hasConcept C530470458 @default.
• W2058476722 hasConcept C71924100 @default.

• next