FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058476774> ?p ?o ?g. }

• W2058476774 endingPage "e87762" @default.
• W2058476774 startingPage "e87762" @default.
• W2058476774 abstract "Genome-wide association studies (GWAS) have identified genetic factors in type 2 diabetes (T2D), mostly among individuals of European ancestry. We tested whether previously identified T2D-associated single nucleotide polymorphisms (SNPs) replicate and whether SNPs in regions near known T2D SNPs were associated with T2D within the Singapore Chinese Health Study.2338 cases and 2339 T2D controls from the Singapore Chinese Health Study were genotyped for 507,509 SNPs. Imputation extended the genotyped SNPs to 7,514,461 with high estimated certainty (r(2)>0.8). Replication of known index SNP associations in T2D was attempted. Risk scores were computed as the sum of index risk alleles. SNPs in regions ± 100 kb around each index were tested for associations with T2D in conditional fine-mapping analysis.Of 69 index SNPs, 20 were genotyped directly and genotypes at 35 others were well imputed. Among the 55 SNPs with data, disease associations were replicated (at p<0.05) for 15 SNPs, while 32 more were directionally consistent with previous reports. Risk score was a significant predictor with a 2.03 fold higher risk CI (1.69-2.44) of T2D comparing the highest to lowest quintile of risk allele burden (p = 5.72 × 10(-14)). Two improved SNPs around index rs10923931 and 5 new candidate SNPs around indices rs10965250 and rs1111875 passed simple Bonferroni corrections for significance in conditional analysis. Nonetheless, only a small fraction (2.3% on the disease liability scale) of T2D burden in Singapore is explained by these SNPs.While diabetes risk in Singapore Chinese involves genetic variants, most disease risk remains unexplained. Further genetic work is ongoing in the Singapore Chinese population to identify unique common variants not already seen in earlier studies. However rapid increases in T2D risk have occurred in recent decades in this population, indicating that dynamic environmental influences and possibly gene by environment interactions complicate the genetic architecture of this disease." @default.
• W2058476774 created "2016-06-24" @default.
• W2058476774 creator A5005173157 @default.
• W2058476774 creator A5019496865 @default.
• W2058476774 creator A5033141774 @default.
• W2058476774 creator A5035282947 @default.
• W2058476774 creator A5037846755 @default.
• W2058476774 creator A5041191262 @default.
• W2058476774 creator A5045254063 @default.
• W2058476774 creator A5046710077 @default.
• W2058476774 creator A5049068947 @default.
• W2058476774 creator A5063230233 @default.
• W2058476774 creator A5063652834 @default.
• W2058476774 creator A5070986676 @default.
• W2058476774 creator A5071171458 @default.
• W2058476774 creator A5074117254 @default.
• W2058476774 creator A5091745588 @default.
• W2058476774 date "2014-02-10" @default.
• W2058476774 modified "2023-10-04" @default.
• W2058476774 title "Joint Effects of Known Type 2 Diabetes Susceptibility Loci in Genome-Wide Association Study of Singapore Chinese: The Singapore Chinese Health Study" @default.
• W2058476774 cites W111389384 @default.
• W2058476774 cites W1485161311 @default.
• W2058476774 cites W1513833217 @default.
• W2058476774 cites W1855576760 @default.
• W2058476774 cites W1944558458 @default.
• W2058476774 cites W1965141016 @default.
• W2058476774 cites W1971751459 @default.
• W2058476774 cites W1976210931 @default.
• W2058476774 cites W1978215768 @default.
• W2058476774 cites W1980991473 @default.
• W2058476774 cites W1984074308 @default.
• W2058476774 cites W1984407806 @default.
• W2058476774 cites W1989970381 @default.
• W2058476774 cites W1991704577 @default.
• W2058476774 cites W1992297169 @default.
• W2058476774 cites W1992436001 @default.
• W2058476774 cites W1996189760 @default.
• W2058476774 cites W2001956441 @default.
• W2058476774 cites W2004299376 @default.
• W2058476774 cites W2009020864 @default.
• W2058476774 cites W2010282186 @default.
• W2058476774 cites W2015592408 @default.
• W2058476774 cites W2020267609 @default.
• W2058476774 cites W2025086473 @default.
• W2058476774 cites W2025143098 @default.
• W2058476774 cites W2028234345 @default.
• W2058476774 cites W2028941345 @default.
• W2058476774 cites W2033151532 @default.
• W2058476774 cites W2039262609 @default.
• W2058476774 cites W2043219961 @default.
• W2058476774 cites W2043807726 @default.
• W2058476774 cites W2044518560 @default.
• W2058476774 cites W2046952982 @default.
• W2058476774 cites W2048755332 @default.
• W2058476774 cites W2056526409 @default.
• W2058476774 cites W2058606479 @default.
• W2058476774 cites W2060270800 @default.
• W2058476774 cites W2061539393 @default.
• W2058476774 cites W2074389004 @default.
• W2058476774 cites W2074665385 @default.
• W2058476774 cites W2076450470 @default.
• W2058476774 cites W2077397717 @default.
• W2058476774 cites W2082122713 @default.
• W2058476774 cites W2083630211 @default.
• W2058476774 cites W2084464990 @default.
• W2058476774 cites W2085881951 @default.
• W2058476774 cites W2087354333 @default.
• W2058476774 cites W2090757087 @default.
• W2058476774 cites W2095645712 @default.
• W2058476774 cites W2100608922 @default.
• W2058476774 cites W2103686740 @default.
• W2058476774 cites W2114688149 @default.
• W2058476774 cites W2122203297 @default.
• W2058476774 cites W2132610273 @default.
• W2058476774 cites W2134783591 @default.
• W2058476774 cites W2137353408 @default.
• W2058476774 cites W2141642891 @default.
• W2058476774 cites W2142965222 @default.
• W2058476774 cites W2146348844 @default.
• W2058476774 cites W2146628154 @default.
• W2058476774 cites W2146809629 @default.
• W2058476774 cites W2150088209 @default.
• W2058476774 cites W2158822657 @default.
• W2058476774 cites W2159560084 @default.
• W2058476774 cites W2159806894 @default.
• W2058476774 cites W2160115185 @default.
• W2058476774 cites W2161261572 @default.
• W2058476774 cites W2161633633 @default.
• W2058476774 cites W2163013660 @default.
• W2058476774 cites W2166856678 @default.
• W2058476774 cites W2169174186 @default.
• W2058476774 cites W2169189827 @default.
• W2058476774 cites W2171233986 @default.
• W2058476774 cites W2171723172 @default.
• W2058476774 cites W2171777347 @default.
• W2058476774 cites W2471558455 @default.
• W2058476774 cites W2915985519 @default.
• W2058476774 cites W2065287218 @default.

• next