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- W2058477084 abstract "The addition of arginine to the growth medium of an Escherichia coli W mutant leads to the simultaneous induction of synthesis of acetylornithine δ-transaminase and burst of synthesis of acetylornithinase; the hurst of acetylornithinase synthesis is followed by the repression of synthesis of acetylornithinase. Chloramphenicol prevents the induction of acetylornithine δ-transaminase and acetylornithinase, indicating that the observed increase in activity is not due solely to either activation of preformed enzyme or to association of completed subunits. Trimethoprim will not prevent the synthesis of either of these enzymes. Rifampin, an inhibitor of the initiation of transcription, likewise is ineffective as an inhibitor of the synthesis of both of these enzymes. Actinomycin D, on the other hand, inhibits arginine-induced synthesis of acetylornithine δ-transaminase as well as the burst of synthesis of acetylornithinase. Since synthesis of acetylornithine δ-transaminase and acetylornithinase appears to be regulated at a point beyond initiation of transcription and translation, a model is proposed in which transcription and translation are physically coupled. The synchrony of these two processes is governed by the intracellular concentration of arginine." @default.
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- W2058477084 date "1973-11-01" @default.
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- W2058477084 title "Inhibition of transcription and translation of an arginine-induced and rifampin-induced acetylornithine δ-transaminase of Escherichia coli" @default.
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- W2058477084 doi "https://doi.org/10.1016/0003-9861(73)90448-7" @default.
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