FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058477557> ?p ?o ?g. }

• W2058477557 endingPage "423" @default.
• W2058477557 startingPage "413" @default.
• W2058477557 abstract "As stem-cell-based therapies rapidly advance toward clinical applications, there is a need for cheap, easily manufactured, injectable gels that can be tailored to carry stem cells and impart function to such cells. Herein we describe a process for making hydrogels composed of hydroxyphenyl propionic acid (HPA) conjugated, branched poly(ethylene glycol) (PEG) via an enzyme mediated, oxidative cross-linking method. Functionalization of the branched PEG with HPA at varying degrees of substitution was confirmed via attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and 1H NMR. The versatility of this hydrogel system was exemplified through variations in the degree of HPA substitution, polymer concentration, and the concentration of cross-linking reagents (horseradish peroxidase and H2O2), which resulted in a range of mechanical properties and gelation kinetics for these gels. Cross-linking of the PEG–HPA conjugate with a recombinantly produced Fibronectin fragment (Type III domains 7–10) encouraged attachment and spreading of human mesenchymal stem cells (hMSCs) when assessed in both two-dimensional and three-dimensional formats. Interestingly, when encapsulated in both nonfunctionalized and functionalized cross-linked PEG–HPA gels, MSCs showed good viability over all time periods assessed. With tunable gelation kinetics and mechanical properties, these hydrogels provide a flexible in vitro cell culture platform that will likely have significant utility in tissue engineering as an injectable delivery platform for cells to sites of tissue damage." @default.
• W2058477557 created "2016-06-24" @default.
• W2058477557 creator A5020029453 @default.
• W2058477557 creator A5033648075 @default.
• W2058477557 creator A5066605681 @default.
• W2058477557 creator A5076063590 @default.
• W2058477557 creator A5082337082 @default.
• W2058477557 creator A5084896557 @default.
• W2058477557 date "2013-01-15" @default.
• W2058477557 modified "2023-09-30" @default.
• W2058477557 title "Tailorable Cell Culture Platforms from Enzymatically Cross-Linked Multifunctional Poly(ethylene glycol)-Based Hydrogels" @default.
• W2058477557 cites W1504989678 @default.
• W2058477557 cites W1964681850 @default.
• W2058477557 cites W1975105372 @default.
• W2058477557 cites W1976971565 @default.
• W2058477557 cites W1977894565 @default.
• W2058477557 cites W1979693489 @default.
• W2058477557 cites W1989277690 @default.
• W2058477557 cites W1990955155 @default.
• W2058477557 cites W2001209511 @default.
• W2058477557 cites W2005048373 @default.
• W2058477557 cites W2006380863 @default.
• W2058477557 cites W2011013435 @default.
• W2058477557 cites W2012601754 @default.
• W2058477557 cites W2022957557 @default.
• W2058477557 cites W2026632078 @default.
• W2058477557 cites W2026780757 @default.
• W2058477557 cites W2027134911 @default.
• W2058477557 cites W2028200036 @default.
• W2058477557 cites W2029090214 @default.
• W2058477557 cites W2032527828 @default.
• W2058477557 cites W2034063548 @default.
• W2058477557 cites W2036501293 @default.
• W2058477557 cites W2039047071 @default.
• W2058477557 cites W2040493814 @default.
• W2058477557 cites W2042646813 @default.
• W2058477557 cites W2043669923 @default.
• W2058477557 cites W2047918257 @default.
• W2058477557 cites W2054635074 @default.
• W2058477557 cites W2061519659 @default.
• W2058477557 cites W2064626771 @default.
• W2058477557 cites W2070596268 @default.
• W2058477557 cites W2072485268 @default.
• W2058477557 cites W2076076808 @default.
• W2058477557 cites W2077644034 @default.
• W2058477557 cites W2103052217 @default.
• W2058477557 cites W2107236297 @default.
• W2058477557 cites W2107554012 @default.
• W2058477557 cites W2113547540 @default.
• W2058477557 cites W2117940877 @default.
• W2058477557 cites W2118614307 @default.
• W2058477557 cites W2126111746 @default.
• W2058477557 cites W2130606072 @default.
• W2058477557 cites W2134208433 @default.
• W2058477557 cites W2150493503 @default.
• W2058477557 cites W2151352042 @default.
• W2058477557 cites W2158778815 @default.
• W2058477557 cites W2164880987 @default.
• W2058477557 cites W2167707151 @default.
• W2058477557 cites W2335091383 @default.
• W2058477557 doi "https://doi.org/10.1021/bm301652q" @default.
• W2058477557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23259935" @default.
• W2058477557 hasPublicationYear "2013" @default.
• W2058477557 type Work @default.
• W2058477557 sameAs 2058477557 @default.
• W2058477557 citedByCount "58" @default.
• W2058477557 countsByYear W20584775572013 @default.
• W2058477557 countsByYear W20584775572014 @default.
• W2058477557 countsByYear W20584775572015 @default.
• W2058477557 countsByYear W20584775572016 @default.
• W2058477557 countsByYear W20584775572017 @default.
• W2058477557 countsByYear W20584775572018 @default.
• W2058477557 countsByYear W20584775572019 @default.
• W2058477557 countsByYear W20584775572020 @default.
• W2058477557 countsByYear W20584775572021 @default.
• W2058477557 countsByYear W20584775572022 @default.
• W2058477557 countsByYear W20584775572023 @default.
• W2058477557 crossrefType "journal-article" @default.
• W2058477557 hasAuthorship W2058477557A5020029453 @default.
• W2058477557 hasAuthorship W2058477557A5033648075 @default.
• W2058477557 hasAuthorship W2058477557A5066605681 @default.
• W2058477557 hasAuthorship W2058477557A5076063590 @default.
• W2058477557 hasAuthorship W2058477557A5082337082 @default.
• W2058477557 hasAuthorship W2058477557A5084896557 @default.
• W2058477557 hasConcept C10138342 @default.
• W2058477557 hasConcept C108586683 @default.
• W2058477557 hasConcept C121332964 @default.
• W2058477557 hasConcept C12554922 @default.
• W2058477557 hasConcept C127413603 @default.
• W2058477557 hasConcept C136229726 @default.
• W2058477557 hasConcept C148898269 @default.
• W2058477557 hasConcept C160892712 @default.
• W2058477557 hasConcept C162324750 @default.
• W2058477557 hasConcept C178790620 @default.
• W2058477557 hasConcept C181199279 @default.
• W2058477557 hasConcept C185592680 @default.
• W2058477557 hasConcept C188027245 @default.
• W2058477557 hasConcept C198826908 @default.

• next