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- W2058478968 abstract "Taxanes, docetaxel and paclitaxel, represent important antineoplastic agents with broad spectra of antitumor activity. The authors developed and validated a high-performance liquid chromatography method with ultraviolet detection for quantifying both taxanes in human plasma. The assay uses liquid-liquid extraction as sample treatment and an isocratic mobile phase and reversed-phase chromatography to determine docetaxel with paclitaxel as internal standard and vice versa. The lower limit of quantification was 0.015 mg/L. The assay had good recovery (87.96±14.05 and 90.57±9.63 for docetaxel and paclitaxel respectively) and precision: the within-day and between-days relative standard deviation of the mean for docetaxel (0.015–3 mg/L) and paclitaxel was always <10%. The method presented has been fully validated following the U.S. Food and Drug Administration requirements and has been successfully applied for the pharmacokinetic investigation of docetaxel or paclitaxel." @default.
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- W2058478968 date "2006-04-01" @default.
- W2058478968 modified "2023-10-10" @default.
- W2058478968 title "Determination of Docetaxel and Paclitaxel in Human Plasma by High-Performance Liquid Chromatography" @default.
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- W2058478968 doi "https://doi.org/10.1097/01.ftd.0000189903.46802.1f" @default.
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