Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058480436> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2058480436 endingPage "162" @default.
- W2058480436 startingPage "154" @default.
- W2058480436 abstract "Normal somatic cells invariably enter a state of permanent growth arrest and altered function after a finite number of divisions. This phenomenon is termed cellular or replicative senescence. Replicative senescence is thought to be a tumor-suppressive mechanism, and a contributing factor in aging. Three features distinguish senescent from presenescent cells: an irreversible block to cell proliferation, increased resistance to apoptotic death, and changes in differentiated functions. Senescence entails an altered pattern of gene expression, much of which is due to altered transcription. At least three growth regulatory transcriptional modulators are repressed in senescent cells: the c-fos component of the API transcription factor, the Id1 and Id2 helix-loop-helix (HLH) proteins that negatively regulate basic HLH transcription factors, and the E2F-1 component of the E2F transcription factor. Failure to express any one of these modulators is very likely sufficient to arrest cell proliferation. Loss of these modulators may also explain many of the functional changes shown by senescent cells. In the case of c-fos repression, the resulting decline in AP-1 activity may be exacerbated by an altered ratio of AP-1 components to a protein known as QM or Jif. QM interacts with the c-jun component of AP-1 and suppresses AP-1 activity. We cloned QM from a senescent fibroblast cDNA library, and found that it was neither cell cycle- nor senescence-regulated. However, QM suppressed the growth of murine and human fibroblasts when overexpressed. Thus, an altered balance between positive factors (e.g., AP-1 components) and negative factors (e.g., QM) may lead to the growth arrest, as well as the changes in differentiated gene expression, that are a hallmark of senescent cells." @default.
- W2058480436 created "2016-06-24" @default.
- W2058480436 creator A5001970748 @default.
- W2058480436 creator A5021447572 @default.
- W2058480436 creator A5063413553 @default.
- W2058480436 creator A5080116569 @default.
- W2058480436 date "1996-01-01" @default.
- W2058480436 modified "2023-09-27" @default.
- W2058480436 title "Replicative Senescence, Aging and Growth-Regulatory Transcription Factors" @default.
- W2058480436 doi "https://doi.org/10.1159/000109185" @default.
- W2058480436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8864060" @default.
- W2058480436 hasPublicationYear "1996" @default.
- W2058480436 type Work @default.
- W2058480436 sameAs 2058480436 @default.
- W2058480436 citedByCount "71" @default.
- W2058480436 countsByYear W20584804362012 @default.
- W2058480436 countsByYear W20584804362013 @default.
- W2058480436 countsByYear W20584804362014 @default.
- W2058480436 countsByYear W20584804362015 @default.
- W2058480436 countsByYear W20584804362017 @default.
- W2058480436 countsByYear W20584804362018 @default.
- W2058480436 countsByYear W20584804362019 @default.
- W2058480436 countsByYear W20584804362020 @default.
- W2058480436 countsByYear W20584804362021 @default.
- W2058480436 countsByYear W20584804362022 @default.
- W2058480436 countsByYear W20584804362023 @default.
- W2058480436 crossrefType "journal-article" @default.
- W2058480436 hasAuthorship W2058480436A5001970748 @default.
- W2058480436 hasAuthorship W2058480436A5021447572 @default.
- W2058480436 hasAuthorship W2058480436A5063413553 @default.
- W2058480436 hasAuthorship W2058480436A5080116569 @default.
- W2058480436 hasConcept C104317684 @default.
- W2058480436 hasConcept C134305767 @default.
- W2058480436 hasConcept C138885662 @default.
- W2058480436 hasConcept C179926584 @default.
- W2058480436 hasConcept C29537977 @default.
- W2058480436 hasConcept C41895202 @default.
- W2058480436 hasConcept C522857546 @default.
- W2058480436 hasConcept C54355233 @default.
- W2058480436 hasConcept C6174537 @default.
- W2058480436 hasConcept C62112901 @default.
- W2058480436 hasConcept C83258922 @default.
- W2058480436 hasConcept C86339819 @default.
- W2058480436 hasConcept C86803240 @default.
- W2058480436 hasConcept C94966510 @default.
- W2058480436 hasConcept C95444343 @default.
- W2058480436 hasConceptScore W2058480436C104317684 @default.
- W2058480436 hasConceptScore W2058480436C134305767 @default.
- W2058480436 hasConceptScore W2058480436C138885662 @default.
- W2058480436 hasConceptScore W2058480436C179926584 @default.
- W2058480436 hasConceptScore W2058480436C29537977 @default.
- W2058480436 hasConceptScore W2058480436C41895202 @default.
- W2058480436 hasConceptScore W2058480436C522857546 @default.
- W2058480436 hasConceptScore W2058480436C54355233 @default.
- W2058480436 hasConceptScore W2058480436C6174537 @default.
- W2058480436 hasConceptScore W2058480436C62112901 @default.
- W2058480436 hasConceptScore W2058480436C83258922 @default.
- W2058480436 hasConceptScore W2058480436C86339819 @default.
- W2058480436 hasConceptScore W2058480436C86803240 @default.
- W2058480436 hasConceptScore W2058480436C94966510 @default.
- W2058480436 hasConceptScore W2058480436C95444343 @default.
- W2058480436 hasIssue "3" @default.
- W2058480436 hasLocation W20584804361 @default.
- W2058480436 hasLocation W20584804362 @default.
- W2058480436 hasOpenAccess W2058480436 @default.
- W2058480436 hasPrimaryLocation W20584804361 @default.
- W2058480436 hasRelatedWork W1481014355 @default.
- W2058480436 hasRelatedWork W1492034352 @default.
- W2058480436 hasRelatedWork W1993502357 @default.
- W2058480436 hasRelatedWork W2055123321 @default.
- W2058480436 hasRelatedWork W2116733668 @default.
- W2058480436 hasRelatedWork W2425734257 @default.
- W2058480436 hasRelatedWork W2532041 @default.
- W2058480436 hasRelatedWork W3209090203 @default.
- W2058480436 hasRelatedWork W4244660752 @default.
- W2058480436 hasRelatedWork W4280493527 @default.
- W2058480436 hasVolume "5" @default.
- W2058480436 isParatext "false" @default.
- W2058480436 isRetracted "false" @default.
- W2058480436 magId "2058480436" @default.
- W2058480436 workType "article" @default.