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- W2058483193 abstract "Recent findings indicate that ischemia/reperfusion (IR) is associated with phospholipase C (PLC)-induced inositol 1,4,5-triphosphate production, as well as abnormal sarcoplasmic reticulum (SR) Ca2+ release. Therefore, we hypothesized that increased SR Ca2+ release may contribute to Ca2+ overload and myocardial stunning. Neomycin (NEO) was used to inhibit PLC, and sodium dantrolene (DAN) was used to inhibit myocardial SR Ca2+ release. The purposes of this study were (1) to determine if PLC inhibition would reduce IR-induced ventricular dysfunction, (2) to examine ventricular function during inhibition of SR Ca2+ release prior to ischemia, and (3) to examine the influence of SR Ca2+ release inhibition on post-IR ventricular function. Left ventricular developed pressure (DP) and ±dP/dt of isolated crystalloid perfused rat heart (Langendorff apparatus) paced at 350 bpm were compared before and after global IR (38°C, 20 min I, 40 min R) to assess functional recovery. PLC was inhibited with NEO (10 μM × 5 min prior to ischemia), and SR Ca2+ release was retarded with DAN (12.5 μM) in 0.05% DMSO (vehicle) infused for 3 min via the aortic canula 13 min prior to ischemia. No effect on DP was observed during NEO or DAN infusion. NEO and DAN pretreatment each improved recovery of DP (% recovery ± SEM) following IR: control, 46.5 ± 5.1%; NEO + IR, 71.0 ± 6.3%,* vehicle + IR, 44.4 ± 2.9%; DAN + IR, 71.0 ± 4.7%,*,† (*P < 0.05 vs control IR, †P < 0.05 vs vehicle + IR, ANOVA, Scheffe F test, n = 5 all groups). We conclude that SR Ca2+ release during IR contributes to myocardial stunning." @default.
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- W2058483193 date "1993-05-01" @default.
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- W2058483193 title "Inhibition of Sarcoplasmic Reticulum Calcium Release Reduces Myocardial Stunning" @default.
- W2058483193 doi "https://doi.org/10.1006/jsre.1993.1065" @default.
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