FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058488554> ?p ?o ?g. }

• W2058488554 endingPage "890" @default.
• W2058488554 startingPage "883" @default.
• W2058488554 abstract "Specific immunotherapy involving systemic injection of allergen, though highly effective, can cause severe side effects due to IgE-mediated activation of effector cells. Allergen-derived peptides might provide a safer alternative. We have investigated the use of mucosally delivered peptide to induce CD4(+) T(H)2 cell tolerance and thus protect against allergen-induced airway inflammation.The purpose of this study was to investigate whether intranasal administration of an allergen-derived peptide, either alone or adsorbed to chitosan, can prevent the induction of T(H)2-mediated pulmonary inflammation after sensitization and challenge of the airways with allergen.Mice were given (intranasally) a peptide containing an immunodominant epitope of the Dermatophagoides pteronyssinus (Der p) 1 allergen, either as soluble antigen or adsorbed to chitosan, before sensitization and allergen challenge. Pulmonary inflammation, antigen-specific CD4(+) T-cell responses, and antibody levels in sera were then determined.Mice given peptide adsorbed to chitosan had significant reductions in airway eosinophilia, which correlated with reduced levels of IL-4 and IL-5 in the bronchoalveolar lavage fluid. There was decreased recruitment of activated CD4(+) T cells into the airways after allergen challenge, which correlated with a loss of Der p 1-specific T-cell cytokine responses in the periphery and the localized production of IL-10 by antigen-specific T cells in bronchial lymph nodes. Induction of peripheral T-cell tolerance was preceded by transient T-cell activation and IFN-gamma production.Our data demonstrate that suppression of airway inflammation by intranasal administration of peptide antigen adsorbed to chitosan is initiated by transient T-cell activation and maintained by the production of IL-10 by antigen-specific T cells in the draining lymph nodes." @default.
• W2058488554 created "2016-06-24" @default.
• W2058488554 creator A5023875950 @default.
• W2058488554 creator A5027836292 @default.
• W2058488554 creator A5035925532 @default.
• W2058488554 creator A5042525593 @default.
• W2058488554 date "2002-12-01" @default.
• W2058488554 modified "2023-10-17" @default.
• W2058488554 title "Kinetics and mode of peptide delivery via the respiratory mucosa determine the outcome of activation versus TH2 immunity in allergic inflammation of the airways" @default.
• W2058488554 cites W1238203966 @default.
• W2058488554 cites W1484235628 @default.
• W2058488554 cites W1488377901 @default.
• W2058488554 cites W1493122966 @default.
• W2058488554 cites W1532147512 @default.
• W2058488554 cites W1539208643 @default.
• W2058488554 cites W1548751297 @default.
• W2058488554 cites W1574786557 @default.
• W2058488554 cites W1593964246 @default.
• W2058488554 cites W1611935467 @default.
• W2058488554 cites W2018664427 @default.
• W2058488554 cites W2021399618 @default.
• W2058488554 cites W2023152671 @default.
• W2058488554 cites W2040066315 @default.
• W2058488554 cites W2040838085 @default.
• W2058488554 cites W2043837854 @default.
• W2058488554 cites W2043851379 @default.
• W2058488554 cites W2046713296 @default.
• W2058488554 cites W2046842929 @default.
• W2058488554 cites W2049432379 @default.
• W2058488554 cites W2066352783 @default.
• W2058488554 cites W2075875408 @default.
• W2058488554 cites W2116313488 @default.
• W2058488554 cites W2117595099 @default.
• W2058488554 cites W2124621398 @default.
• W2058488554 cites W2127404676 @default.
• W2058488554 cites W2141895910 @default.
• W2058488554 cites W2152044788 @default.
• W2058488554 cites W2155666356 @default.
• W2058488554 cites W2158860741 @default.
• W2058488554 cites W2159881353 @default.
• W2058488554 cites W2163037816 @default.
• W2058488554 cites W2312870247 @default.
• W2058488554 cites W2564152524 @default.
• W2058488554 doi "https://doi.org/10.1067/mai.2002.129800" @default.
• W2058488554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12464955" @default.
• W2058488554 hasPublicationYear "2002" @default.
• W2058488554 type Work @default.
• W2058488554 sameAs 2058488554 @default.
• W2058488554 citedByCount "22" @default.
• W2058488554 countsByYear W20584885542012 @default.
• W2058488554 countsByYear W20584885542013 @default.
• W2058488554 countsByYear W20584885542016 @default.
• W2058488554 countsByYear W20584885542017 @default.
• W2058488554 countsByYear W20584885542022 @default.
• W2058488554 crossrefType "journal-article" @default.
• W2058488554 hasAuthorship W2058488554A5023875950 @default.
• W2058488554 hasAuthorship W2058488554A5027836292 @default.
• W2058488554 hasAuthorship W2058488554A5035925532 @default.
• W2058488554 hasAuthorship W2058488554A5042525593 @default.
• W2058488554 hasBestOaLocation W20584885541 @default.
• W2058488554 hasConcept C126322002 @default.
• W2058488554 hasConcept C141105273 @default.
• W2058488554 hasConcept C147483822 @default.
• W2058488554 hasConcept C159654299 @default.
• W2058488554 hasConcept C203014093 @default.
• W2058488554 hasConcept C207480886 @default.
• W2058488554 hasConcept C2776090121 @default.
• W2058488554 hasConcept C2776217527 @default.
• W2058488554 hasConcept C2776914184 @default.
• W2058488554 hasConcept C2777714996 @default.
• W2058488554 hasConcept C2777961210 @default.
• W2058488554 hasConcept C2779675166 @default.
• W2058488554 hasConcept C2780510475 @default.
• W2058488554 hasConcept C71924100 @default.
• W2058488554 hasConcept C85663871 @default.
• W2058488554 hasConcept C8891405 @default.
• W2058488554 hasConceptScore W2058488554C126322002 @default.
• W2058488554 hasConceptScore W2058488554C141105273 @default.
• W2058488554 hasConceptScore W2058488554C147483822 @default.
• W2058488554 hasConceptScore W2058488554C159654299 @default.
• W2058488554 hasConceptScore W2058488554C203014093 @default.
• W2058488554 hasConceptScore W2058488554C207480886 @default.
• W2058488554 hasConceptScore W2058488554C2776090121 @default.
• W2058488554 hasConceptScore W2058488554C2776217527 @default.
• W2058488554 hasConceptScore W2058488554C2776914184 @default.
• W2058488554 hasConceptScore W2058488554C2777714996 @default.
• W2058488554 hasConceptScore W2058488554C2777961210 @default.
• W2058488554 hasConceptScore W2058488554C2779675166 @default.
• W2058488554 hasConceptScore W2058488554C2780510475 @default.
• W2058488554 hasConceptScore W2058488554C71924100 @default.
• W2058488554 hasConceptScore W2058488554C85663871 @default.
• W2058488554 hasConceptScore W2058488554C8891405 @default.
• W2058488554 hasIssue "6" @default.
• W2058488554 hasLocation W20584885541 @default.
• W2058488554 hasLocation W20584885542 @default.
• W2058488554 hasOpenAccess W2058488554 @default.
• W2058488554 hasPrimaryLocation W20584885541 @default.
• W2058488554 hasRelatedWork W2027770339 @default.

• next