FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058492759> ?p ?o ?g. }

• W2058492759 endingPage "110" @default.
• W2058492759 startingPage "100" @default.
• W2058492759 abstract "Disorder of mucosal immunity based on an imbalance between proinflammatory and anti-inflammatory cytokines is believed to be a major factor in the pathogenesis of ulcerative colitis. Platelet-activating factor potentially stimulates the production of proinflammatory cytokines and recruits inflammatory cells. The aim of this study was to determine whether and to what extent platelet-activating factor plays a role in the pathogenesis of ulcerative colitis.Using dextran sulfate sodium-induced colitis in rats as a model of ulcerative colitis, we analyzed the composition of cellular infiltrates and the local tissue expression of messenger ribonucleic acid for cytokine-induced neutrophil chemoattractant and tumor necrosis factor-alpha. To directly assess the impact of platelet-activating factor on the development of colitis, we also determined the efficacy of a specific platelet-activating factor receptor antagonist for preventing dextran sulfate sodium-induced colitis.The activity of colitis was well correlated with the upregulation of cytokine-induced neutrophil chemoattractant and tumor necrosis factor-alpha messenger ribonucleic acid in local tissues and infiltration of cytokine-induced neutrophil chemoattractant-positive neutrophils and ED1-positive macrophages. The platelet-activating factor receptor antagonist effectively ameliorated colitis, along with causing a decrease in the tissue cytokine-induced neutrophil chemoattractant messenger ribonucleic acid level and a decline in neutrophil and macrophage infiltration. However, the antagonist did not alter tissue levels of tumor necrosis factor-alpha messenger ribonucleic acid.Platelet-activating factor plays a critical role in the pathogenesis of dextran sulfate sodium-induced colitis through recruitment of cytokine-induced neutrophil chemoattractant-positive neutrophils and macrophages and/or stimulation of cytokine-induced neutrophil chemoattractant release from activated neutrophils. The tissue level of tumor necrosis factor-alpha messenger ribonucleic acid does not closely reflect the activity of colitis." @default.
• W2058492759 created "2016-06-24" @default.
• W2058492759 creator A5001368917 @default.
• W2058492759 creator A5008405600 @default.
• W2058492759 creator A5037716396 @default.
• W2058492759 creator A5038084637 @default.
• W2058492759 creator A5045341349 @default.
• W2058492759 creator A5073911875 @default.
• W2058492759 creator A5088773176 @default.
• W2058492759 date "2003-01-01" @default.
• W2058492759 modified "2023-10-13" @default.
• W2058492759 title "Platelet-Activating Factor, a Critical Mediator in the Pathogenesis of Dextran Sulfate Sodium-Induced Colitis in Rats" @default.
• W2058492759 cites W1547303097 @default.
• W2058492759 cites W1599847784 @default.
• W2058492759 cites W1658068887 @default.
• W2058492759 cites W1670771883 @default.
• W2058492759 cites W179793388 @default.
• W2058492759 cites W1813646352 @default.
• W2058492759 cites W1855226200 @default.
• W2058492759 cites W1937180445 @default.
• W2058492759 cites W1946093640 @default.
• W2058492759 cites W1953009759 @default.
• W2058492759 cites W1954354169 @default.
• W2058492759 cites W1966961395 @default.
• W2058492759 cites W1983658244 @default.
• W2058492759 cites W1983949301 @default.
• W2058492759 cites W1993210315 @default.
• W2058492759 cites W1997677936 @default.
• W2058492759 cites W2000997159 @default.
• W2058492759 cites W2008856924 @default.
• W2058492759 cites W2009980852 @default.
• W2058492759 cites W2010501154 @default.
• W2058492759 cites W2011199158 @default.
• W2058492759 cites W2024513902 @default.
• W2058492759 cites W2040794042 @default.
• W2058492759 cites W2050193104 @default.
• W2058492759 cites W2051267141 @default.
• W2058492759 cites W2056135553 @default.
• W2058492759 cites W2056334753 @default.
• W2058492759 cites W2057710511 @default.
• W2058492759 cites W206604000 @default.
• W2058492759 cites W20761558 @default.
• W2058492759 cites W2076460434 @default.
• W2058492759 cites W2083158017 @default.
• W2058492759 cites W2085304257 @default.
• W2058492759 cites W2090068706 @default.
• W2058492759 cites W2091239442 @default.
• W2058492759 cites W2113842263 @default.
• W2058492759 cites W2129889907 @default.
• W2058492759 cites W2137630301 @default.
• W2058492759 cites W2141267620 @default.
• W2058492759 cites W2146906769 @default.
• W2058492759 cites W2154232005 @default.
• W2058492759 cites W2157360106 @default.
• W2058492759 cites W2176899369 @default.
• W2058492759 cites W2394917029 @default.
• W2058492759 cites W2396370145 @default.
• W2058492759 cites W2409103008 @default.
• W2058492759 cites W2417740291 @default.
• W2058492759 cites W2418823269 @default.
• W2058492759 cites W2443129470 @default.
• W2058492759 cites W2468468747 @default.
• W2058492759 cites W8936490 @default.
• W2058492759 doi "https://doi.org/10.1007/s10350-004-6503-7" @default.
• W2058492759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12544529" @default.
• W2058492759 hasPublicationYear "2003" @default.
• W2058492759 type Work @default.
• W2058492759 sameAs 2058492759 @default.
• W2058492759 citedByCount "5" @default.
• W2058492759 countsByYear W20584927592019 @default.
• W2058492759 countsByYear W20584927592021 @default.
• W2058492759 crossrefType "journal-article" @default.
• W2058492759 hasAuthorship W2058492759A5001368917 @default.
• W2058492759 hasAuthorship W2058492759A5008405600 @default.
• W2058492759 hasAuthorship W2058492759A5037716396 @default.
• W2058492759 hasAuthorship W2058492759A5038084637 @default.
• W2058492759 hasAuthorship W2058492759A5045341349 @default.
• W2058492759 hasAuthorship W2058492759A5073911875 @default.
• W2058492759 hasAuthorship W2058492759A5088773176 @default.
• W2058492759 hasConcept C126322002 @default.
• W2058492759 hasConcept C164027704 @default.
• W2058492759 hasConcept C170493617 @default.
• W2058492759 hasConcept C17991360 @default.
• W2058492759 hasConcept C203014093 @default.
• W2058492759 hasConcept C2775862500 @default.
• W2058492759 hasConcept C2776885963 @default.
• W2058492759 hasConcept C2776914184 @default.
• W2058492759 hasConcept C2778690821 @default.
• W2058492759 hasConcept C2779020240 @default.
• W2058492759 hasConcept C2779134260 @default.
• W2058492759 hasConcept C2780479503 @default.
• W2058492759 hasConcept C2780942790 @default.
• W2058492759 hasConcept C2780955469 @default.
• W2058492759 hasConcept C71924100 @default.
• W2058492759 hasConceptScore W2058492759C126322002 @default.
• W2058492759 hasConceptScore W2058492759C164027704 @default.
• W2058492759 hasConceptScore W2058492759C170493617 @default.
• W2058492759 hasConceptScore W2058492759C17991360 @default.

• next