FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058508022> ?p ?o ?g. }

• W2058508022 endingPage "656" @default.
• W2058508022 startingPage "650" @default.
• W2058508022 abstract "Chagas' disease, caused by Trypanosoma cruzi, has an acute phase characterized by blood-circulating trypomastigotes and amastigote proliferation in several cell types, especially muscle cells. In the chronic phase, around 70% of infected people are asymptomatic (latent form). The remainder develop chagasic cardiomyopathy and/or digestive syndromes. There is evidence for aggravation of the chronic cardiac pathology by endothelin-mediated vasoconstriction. Holtzman rats have proven to be a good model for Chagas' disease acute phase and latent chronic phase. Now, we investigate the effects of prolonged treatment with an endothelin ET(A) receptor antagonist, BSF 461314, during the acute phase on parasitemia, coronary flow, tissue parasitism and the inflammatory process. Using isolated heart in Langendorff's preparation, endothelial dysfunction was observed only in non-treated infected animals. Histoquantitative analyses carried out in heart and diaphragm showed higher tissue parasitism and/or inflammatory process in BSF 461314-treated animals. Our data indicate that endothelin ET(A) receptors contribute to the initial mechanisms of parasite control. Impairment of the endothelium-dependent vasodilatation favors hazardous effects. However, blocking endothelin ET(A) receptors can prevent the latter." @default.
• W2058508022 created "2016-06-24" @default.
• W2058508022 creator A5014426469 @default.
• W2058508022 creator A5024470446 @default.
• W2058508022 creator A5029441169 @default.
• W2058508022 creator A5037744205 @default.
• W2058508022 creator A5048839940 @default.
• W2058508022 creator A5053654313 @default.
• W2058508022 creator A5055470223 @default.
• W2058508022 creator A5060993179 @default.
• W2058508022 creator A5070885560 @default.
• W2058508022 creator A5080148786 @default.
• W2058508022 date "2004-06-01" @default.
• W2058508022 modified "2023-09-22" @default.
• W2058508022 title "Protective role of ETA endothelin receptors during the acute phase of Trypanosoma cruzi infection in rats" @default.
• W2058508022 cites W1768923368 @default.
• W2058508022 cites W1781491504 @default.
• W2058508022 cites W1926753936 @default.
• W2058508022 cites W1964869550 @default.
• W2058508022 cites W1969347062 @default.
• W2058508022 cites W1972461395 @default.
• W2058508022 cites W1983324123 @default.
• W2058508022 cites W1998523124 @default.
• W2058508022 cites W2003897881 @default.
• W2058508022 cites W2008771858 @default.
• W2058508022 cites W2011449949 @default.
• W2058508022 cites W2037272967 @default.
• W2058508022 cites W2040251787 @default.
• W2058508022 cites W2040652079 @default.
• W2058508022 cites W2042510395 @default.
• W2058508022 cites W2042812974 @default.
• W2058508022 cites W2045282478 @default.
• W2058508022 cites W2061446590 @default.
• W2058508022 cites W2061682911 @default.
• W2058508022 cites W2068859028 @default.
• W2058508022 cites W2128544050 @default.
• W2058508022 cites W2134063875 @default.
• W2058508022 cites W2137372191 @default.
• W2058508022 cites W2147440566 @default.
• W2058508022 cites W2147892745 @default.
• W2058508022 cites W2148663698 @default.
• W2058508022 cites W2162804111 @default.
• W2058508022 cites W2171131376 @default.
• W2058508022 cites W2223739663 @default.
• W2058508022 cites W2329965891 @default.
• W2058508022 cites W2331465631 @default.
• W2058508022 cites W4211027594 @default.
• W2058508022 doi "https://doi.org/10.1016/j.micinf.2004.03.002" @default.
• W2058508022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15158772" @default.
• W2058508022 hasPublicationYear "2004" @default.
• W2058508022 type Work @default.
• W2058508022 sameAs 2058508022 @default.
• W2058508022 citedByCount "20" @default.
• W2058508022 countsByYear W20585080222012 @default.
• W2058508022 countsByYear W20585080222013 @default.
• W2058508022 countsByYear W20585080222016 @default.
• W2058508022 crossrefType "journal-article" @default.
• W2058508022 hasAuthorship W2058508022A5014426469 @default.
• W2058508022 hasAuthorship W2058508022A5024470446 @default.
• W2058508022 hasAuthorship W2058508022A5029441169 @default.
• W2058508022 hasAuthorship W2058508022A5037744205 @default.
• W2058508022 hasAuthorship W2058508022A5048839940 @default.
• W2058508022 hasAuthorship W2058508022A5053654313 @default.
• W2058508022 hasAuthorship W2058508022A5055470223 @default.
• W2058508022 hasAuthorship W2058508022A5060993179 @default.
• W2058508022 hasAuthorship W2058508022A5070885560 @default.
• W2058508022 hasAuthorship W2058508022A5080148786 @default.
• W2058508022 hasConcept C112418997 @default.
• W2058508022 hasConcept C126322002 @default.
• W2058508022 hasConcept C136764020 @default.
• W2058508022 hasConcept C144980905 @default.
• W2058508022 hasConcept C170493617 @default.
• W2058508022 hasConcept C203014093 @default.
• W2058508022 hasConcept C2775867548 @default.
• W2058508022 hasConcept C2777625466 @default.
• W2058508022 hasConcept C2778048844 @default.
• W2058508022 hasConcept C2778371730 @default.
• W2058508022 hasConcept C41008148 @default.
• W2058508022 hasConcept C55493867 @default.
• W2058508022 hasConcept C71924100 @default.
• W2058508022 hasConcept C71928629 @default.
• W2058508022 hasConcept C86803240 @default.
• W2058508022 hasConceptScore W2058508022C112418997 @default.
• W2058508022 hasConceptScore W2058508022C126322002 @default.
• W2058508022 hasConceptScore W2058508022C136764020 @default.
• W2058508022 hasConceptScore W2058508022C144980905 @default.
• W2058508022 hasConceptScore W2058508022C170493617 @default.
• W2058508022 hasConceptScore W2058508022C203014093 @default.
• W2058508022 hasConceptScore W2058508022C2775867548 @default.
• W2058508022 hasConceptScore W2058508022C2777625466 @default.
• W2058508022 hasConceptScore W2058508022C2778048844 @default.
• W2058508022 hasConceptScore W2058508022C2778371730 @default.
• W2058508022 hasConceptScore W2058508022C41008148 @default.
• W2058508022 hasConceptScore W2058508022C55493867 @default.
• W2058508022 hasConceptScore W2058508022C71924100 @default.
• W2058508022 hasConceptScore W2058508022C71928629 @default.
• W2058508022 hasConceptScore W2058508022C86803240 @default.
• W2058508022 hasIssue "7" @default.

• next