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• W2058512912 abstract "Significance Pathogens express virulence factors to support their growth and reproduction while hosts activate various immune processes to promote pathogen clearance and minimize damage. In this study, we establish a new role for pyoverdin, an iron-binding siderophore produced by the bacterium Pseudomonas aeruginosa . In addition to promoting growth by acquiring iron, pyoverdin serves as a secreted bacterial toxin that disrupts mitochondria and iron homeostasis in Caenorhabditis elegans . We show that exposure to pyoverdin triggers mitochondrial damage and subsequent mitophagy (lysosomal degradation of damaged mitochondria). Importantly, mitophagy confers a protective effect against exposure to either pyoverdin or to a synthetic iron chelator, demonstrating a function for mitophagy in innate immunity. Finally, we show that iron chelation causes mitophagy in mammalian cells." @default.
• W2058512912 created "2016-06-24" @default.
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• W2058512912 creator A5076196713 @default.
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• W2058512912 date "2015-01-26" @default.
• W2058512912 modified "2023-10-16" @default.
• W2058512912 title "Mitophagy confers resistance to siderophore-mediated killing by <i>Pseudomonas aeruginosa</i>" @default.
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• W2058512912 doi "https://doi.org/10.1073/pnas.1424954112" @default.
• W2058512912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4330731" @default.
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