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• W2058520977 abstract "The <i>KIBRA</i> gene has been associated with episodic memory in several recent reports; carriers of the T-allele show enhanced episodic memory performance relative to noncarriers. Gene expression studies in human and rodent species show high levels of <i>KIBRA</i> in the hippocampus, particularly in the subfields. The goal of the present study was to determine whether the <i>KIBRA</i> C→T polymorphism is also associated with volume differences in the human hippocampus and whether specific subfields are differentially affected by <i>KIBRA</i> genotype. High-resolution magnetic resonance imaging (T2-weighted, voxel size = 0.4 × 0.4 mm, in-plane) was used to manually segment hippocampal cornu ammonis (CA) subfields, dentate gyrus (DG), and the subiculum as well as adjacent medial temporal lobe cortices in healthy carriers and noncarriers of the <i>KIBRA</i> T-allele (rs17070145). Overall, we found that T-carriers had a larger hippocampal volume relative to noncarriers. The structural differences observed were specific to the CA fields and DG regions of the hippocampus, suggesting a potential neural mechanism for the effects of <i>KIBRA</i> on episodic memory performance reported previously." @default.
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• W2058520977 date "2013-08-07" @default.
• W2058520977 modified "2023-10-12" @default.
• W2058520977 title "KIBRA Polymorphism Is Associated with Individual Differences in Hippocampal Subregions: Evidence from Anatomical Segmentation using High-Resolution MRI" @default.
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• W2058520977 doi "https://doi.org/10.1523/jneurosci.1406-13.2013" @default.
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