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- W2058526976 abstract "Epigenetic regulation of gene expression is a rapidly growing area of research. Considering the longevity and plasticity of neurons, the studies on epigenetic pathways in the nervous system should be of special interest for both epigeneticists and neuroscientists. Activation or inactivation of different epigenetic pathways becomes more pronounced when the cells experience rapid changes in their environment, and such changes can be easily caused by injury and inflammation, resulting in pain perception or distortion of pain perception (eg, hyperalgesia). Therefore, in this regard, the field of pain is at an advantage to study the epigenetic pathways. More importantly, understanding pain from an epigenetics point of view would provide a new paradigm for developing drugs or strategies for pain management. In this review, we introduce basic concepts of epigenetics, including chromatin dynamics, histone modifications, DNA methylation, and RNA-induced gene silencing. In addition, we provide evidence from published studies suggesting wide implication of different epigenetic pathways within pain pathways.This article provides a brief overview of epigenetic pathways for gene regulation and highlights their involvement in pain. Our goal is to expose the readers to these concepts so that pain-related phenotypes can be investigated from the epigenetic point of view." @default.
- W2058526976 created "2016-06-24" @default.
- W2058526976 creator A5001986186 @default.
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- W2058526976 creator A5077473246 @default.
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- W2058526976 date "2013-06-01" @default.
- W2058526976 modified "2023-09-26" @default.
- W2058526976 title "Epigenetics: A Promising Paradigm for Better Understanding and Managing Pain" @default.
- W2058526976 cites W1549329305 @default.
- W2058526976 cites W1553544470 @default.
- W2058526976 cites W1573817786 @default.
- W2058526976 cites W1583162552 @default.
- W2058526976 cites W1603793127 @default.
- W2058526976 cites W1647075334 @default.
- W2058526976 cites W1687596153 @default.
- W2058526976 cites W1963696308 @default.
- W2058526976 cites W1965262464 @default.
- W2058526976 cites W1965779217 @default.
- W2058526976 cites W1967046460 @default.
- W2058526976 cites W1972017211 @default.
- W2058526976 cites W1972784404 @default.
- W2058526976 cites W1974167091 @default.
- W2058526976 cites W1986464409 @default.
- W2058526976 cites W1987189614 @default.
- W2058526976 cites W1989309280 @default.
- W2058526976 cites W1991893154 @default.
- W2058526976 cites W1992764757 @default.
- W2058526976 cites W1997515675 @default.
- W2058526976 cites W1999284470 @default.
- W2058526976 cites W2002698073 @default.
- W2058526976 cites W2007012438 @default.
- W2058526976 cites W2009981313 @default.
- W2058526976 cites W2010730368 @default.
- W2058526976 cites W2012743573 @default.
- W2058526976 cites W2015949959 @default.
- W2058526976 cites W2016124588 @default.
- W2058526976 cites W2017782459 @default.
- W2058526976 cites W2018373513 @default.
- W2058526976 cites W2023664228 @default.
- W2058526976 cites W2026368142 @default.
- W2058526976 cites W2029388127 @default.
- W2058526976 cites W2030250188 @default.
- W2058526976 cites W2035059547 @default.
- W2058526976 cites W2037541952 @default.
- W2058526976 cites W2040321376 @default.
- W2058526976 cites W2041336616 @default.
- W2058526976 cites W2041587083 @default.
- W2058526976 cites W2044495919 @default.
- W2058526976 cites W2048662553 @default.
- W2058526976 cites W2048958290 @default.
- W2058526976 cites W2049365130 @default.
- W2058526976 cites W2050259276 @default.
- W2058526976 cites W2059229593 @default.
- W2058526976 cites W2060863780 @default.
- W2058526976 cites W2062754747 @default.
- W2058526976 cites W2062832052 @default.
- W2058526976 cites W2070208859 @default.
- W2058526976 cites W2074149762 @default.
- W2058526976 cites W2074380974 @default.
- W2058526976 cites W2075889928 @default.
- W2058526976 cites W2077854844 @default.
- W2058526976 cites W2080911084 @default.
- W2058526976 cites W2080993511 @default.
- W2058526976 cites W2086718779 @default.
- W2058526976 cites W2094248609 @default.
- W2058526976 cites W2096330673 @default.
- W2058526976 cites W2096654038 @default.
- W2058526976 cites W2098967795 @default.
- W2058526976 cites W2100258320 @default.
- W2058526976 cites W2107044736 @default.
- W2058526976 cites W2107153119 @default.
- W2058526976 cites W2107345366 @default.
- W2058526976 cites W2107594198 @default.
- W2058526976 cites W2107635158 @default.
- W2058526976 cites W2107891892 @default.
- W2058526976 cites W2107948836 @default.
- W2058526976 cites W2115802074 @default.
- W2058526976 cites W2123848753 @default.
- W2058526976 cites W2125338577 @default.
- W2058526976 cites W2126627519 @default.
- W2058526976 cites W2126754091 @default.
- W2058526976 cites W2130808015 @default.
- W2058526976 cites W2131110619 @default.
- W2058526976 cites W2134488586 @default.
- W2058526976 cites W2139898757 @default.
- W2058526976 cites W2140872638 @default.
- W2058526976 cites W2141380825 @default.
- W2058526976 cites W2143617365 @default.
- W2058526976 cites W2143658931 @default.
- W2058526976 cites W2147542352 @default.
- W2058526976 cites W2149146453 @default.
- W2058526976 cites W2151794037 @default.
- W2058526976 cites W2155227864 @default.
- W2058526976 cites W2160546783 @default.
- W2058526976 cites W2165038698 @default.