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- W2058528099 abstract "Abstract The incorporation of formate-14C into the cold acid-soluble pool of hepatic adenosine nucleotides was ascertained in rats injected with ethionine. The specific activities and total activities of AMP, ADP, and ATP from ethionine-injected rats averaged 2–6 times those of the control rats at 1, 2, 4, 8, and 20 hr after the labeled formate was given. The specific activity of S-adenosylethionine was similar to that of the adenosine nucleotides. Increased incorporation of formate into the adenosine nucleotides occurred if the formate was injected at the same time as the ethionine, or up to 6 hr later. The injection of methionine alone did not result in an increased incorporation of formate and methionine did not reverse the increased incorporation produced by ethionine. The decrease in adenosine nucleotides caused by ethionine may result in increased de novo synthesis of adenine as a result of release of end-product inhibition. Starvation of the rats for 12 or 18 hr resulted in a marked decrease in the hepatic level of ATP, GTP, and UTP and a slight increase in some of the nucleoside monophosphates." @default.
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- W2058528099 date "1969-02-01" @default.
- W2058528099 modified "2023-09-27" @default.
- W2058528099 title "Stimulation of incorporation of formate-14C into the adenosine nucleotides of the liver of ethionine-injected rats" @default.
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- W2058528099 doi "https://doi.org/10.1016/0003-9861(69)90214-8" @default.
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