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- W2058531788 abstract "Meeting Abstracts1 May 1970Diphenylhydantoin Metabolism in Chronic Uremia.Harlan M. Mellk, M.D., Joseph M. Letteri, M.D., F.A.C.P., Peter Durante, M.D., Sidney Louis, M.D., Henn Kutt, M.D., Anthony Glazko, Ph.D.Harlan M. Mellk, M.D.Search for more papers by this author, Joseph M. Letteri, M.D., F.A.C.P.Search for more papers by this author, Peter Durante, M.D.Search for more papers by this author, Sidney Louis, M.D.Search for more papers by this author, Henn Kutt, M.D.Search for more papers by this author, Anthony Glazko, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-801_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe metabolic fate of diphenylhydantoin, a commonly used anticonvulsant in uremia, is not known. Studies were performed in adult uremic patients with a mean plasma creatinine of 12.6 ± 5 mg/100 ml (range, 5.5 to 22 mg/100 ml). These patients did not receive peritoneal or extracorporeal dialysis during the study. Ten patients received 300 mg of oral diphenylhydantoin daily for 28 days. Mean diphenylhydantoin plasma concentrations at 28 days was 4.7 ± 1.8 μg/ml. In nonuremic individuals equivalent dosage schedules produced concentration of 9.5 ± 4.4 μg/ml, a difference which is highly significant (P< 0.01). Five patients received 400... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: East Meadow and New York, N.Y.; and Ann Arbor, Mich. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffect of Renal Failure and Bis(2-ethylhexyl) Phthalate Pretreatment on the Disposition and Metabolism of Antipyrine in the Rat“In vitro” studies on the fate of diphenylhydantoin in uremiaIndividualization of Dosage of Antiarrhythmic DrugsDrug Selection and Dosage in Renal InsufficiencyUntersuchungen zum Einflu� der Ur�mie auf die Metabolisierung von Phenylbutazon und Aminophenazon beim MenschenProtein Binding of Diphenylhydantoin and Desmethylimipramine in Plasma from Patients with Poor Renal Function 1 May 1970Volume 72, Issue 5Page: 801-801KeywordsAnticonvulsantsAttentionBlood plasmaCreatinineMedical dialysis Issue Published: 1 May 1970 PDF downloadLoading ..." @default.
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- W2058531788 date "1970-05-01" @default.
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- W2058531788 title "Diphenylhydantoin Metabolism in Chronic Uremia." @default.
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