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• W2058537044 startingPage "395" @default.
• W2058537044 abstract "3H-Morphine at physiologic concentration was metabolized in vitro to its 3- and 6-glucuronides by human brain homogenate. Recombinant UGT2B7, one of the UDP-glucuronosyltransferase (UGT) isoforms, is able to glucuronidate the 3- and 6-hydroxy groups of morphine at nanomolar concentrations. These results suggest that endogenous morphine is converted to its 6-glucuronide, a more highly analgesic substance than the parent compound, to suppress effectively pain symptoms in humans." @default.
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• W2058537044 date "2003-01-01" @default.
• W2058537044 modified "2023-10-14" @default.
• W2058537044 title "FORMATION OF HIGHLY ANALGESIC MORPHINE-6-GLUCURONIDE FOLLOWING PHYSIOLOGIC CONCENTRATION OF MORPHINE IN HUMAN BRAIN." @default.
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• W2058537044 doi "https://doi.org/10.2131/jts.28.395" @default.
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