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• W2058541796 abstract "Recent studies have suggested the existence of progenitors common to hematopoietic and endothelial cells, called hemangioblasts, in, for instance, embryonic dorsal aorta. To identify a membrane-bound or secretory molecule regulating early hematopoiesis, we screened a cDNA library from dorsal aortas of embryonic day (E) 10.5 mice by a signal sequence trap method and obtained a clone encoding a sialoprotein, endomucin-1. Immunohistochemistry revealed that the endomucin-1 transcript was specifically expressed in the endothelial cells of dorsal aorta of E10.5 mouse embryo. Overexpression of endomucin-1 strongly inhibited adhesion and aggregation of cells, including cultured endothelial cells from E10.5 dorsal aorta. These data suggest that endomucin-1 may play a role in detachment of hematopoietic cells from endothelium during early hematopoiesis." @default.
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• W2058541796 date "2001-09-01" @default.
• W2058541796 modified "2023-10-03" @default.
• W2058541796 title "Endomucin Is Expressed in Embryonic Dorsal Aorta and Is Able to Inhibit Cell Adhesion" @default.
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• W2058541796 doi "https://doi.org/10.1006/bbrc.2001.5587" @default.
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