Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058543943> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W2058543943 abstract "In order to recognize substantia nigra neuronal changes occurring in aging, 20 human control brains from 13 males and 7 females with a mean age of 61 years (range 20 to 93 years) without neurological disease were examined using the Golgi method. A quantitative study of dendrites and dendritic spines was performed as well as a statistical analysis of obtained data. Parallel sections to the impregnated material were histologically and immunohistologically studied with the aim to identify possible neuronal cytoskeletal abnormalities. Results were compared to changes of substantia nigra reported in other conditions such as Parkinson's disease (PD) and methyl-4-phenylpyridine (MPTP) experimental toxicity. Three different substantia nigra neuronal types were observed. Morphological changes during aging consisted of distorted profile of the cell body and swelling and beading of dendritic branches. The quantitative assessment of changes observed in neuronal types showed a significant loss of dendrites and dendritic spines, especially in the oldest cases. These findings were similar to those previously described in other cerebral areas during aging, but a specific vulnerability of the largest substantia nigra neuronal type could be observed. Nodulations and beaded aspects of dendrites are reminiscent of those changes previously described in MPTP toxicity. Dendritic varicosities found in the oldest cases have also been found in dendrites of large substantia nigra neurons in PD. Cytoskeletal abnormalities have been described in PD but were not found in the present study. Therefore, other pathophysiological mechanisms different from the cytoskeletal compromise occurring in some neurodegenerative diseases should be involved in aging." @default.
- W2058543943 created "2016-06-24" @default.
- W2058543943 creator A5005995811 @default.
- W2058543943 creator A5037247528 @default.
- W2058543943 creator A5060059545 @default.
- W2058543943 date "1995-01-01" @default.
- W2058543943 modified "2023-09-27" @default.
- W2058543943 title "Neuronal Changes in the Substantia Nigra with Aging" @default.
- W2058543943 doi "https://doi.org/10.1097/00005072-199501000-00009" @default.
- W2058543943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7815082" @default.
- W2058543943 hasPublicationYear "1995" @default.
- W2058543943 type Work @default.
- W2058543943 sameAs 2058543943 @default.
- W2058543943 citedByCount "22" @default.
- W2058543943 countsByYear W20585439432013 @default.
- W2058543943 countsByYear W20585439432016 @default.
- W2058543943 countsByYear W20585439432018 @default.
- W2058543943 countsByYear W20585439432019 @default.
- W2058543943 countsByYear W20585439432021 @default.
- W2058543943 crossrefType "journal-article" @default.
- W2058543943 hasAuthorship W2058543943A5005995811 @default.
- W2058543943 hasAuthorship W2058543943A5037247528 @default.
- W2058543943 hasAuthorship W2058543943A5060059545 @default.
- W2058543943 hasConcept C137183658 @default.
- W2058543943 hasConcept C142724271 @default.
- W2058543943 hasConcept C169760540 @default.
- W2058543943 hasConcept C2778674702 @default.
- W2058543943 hasConcept C2780938664 @default.
- W2058543943 hasConcept C513476851 @default.
- W2058543943 hasConcept C71924100 @default.
- W2058543943 hasConcept C86803240 @default.
- W2058543943 hasConceptScore W2058543943C137183658 @default.
- W2058543943 hasConceptScore W2058543943C142724271 @default.
- W2058543943 hasConceptScore W2058543943C169760540 @default.
- W2058543943 hasConceptScore W2058543943C2778674702 @default.
- W2058543943 hasConceptScore W2058543943C2780938664 @default.
- W2058543943 hasConceptScore W2058543943C513476851 @default.
- W2058543943 hasConceptScore W2058543943C71924100 @default.
- W2058543943 hasConceptScore W2058543943C86803240 @default.
- W2058543943 hasLocation W20585439431 @default.
- W2058543943 hasLocation W20585439432 @default.
- W2058543943 hasOpenAccess W2058543943 @default.
- W2058543943 hasPrimaryLocation W20585439431 @default.
- W2058543943 hasRelatedWork W197746683 @default.
- W2058543943 hasRelatedWork W1978654911 @default.
- W2058543943 hasRelatedWork W2020477367 @default.
- W2058543943 hasRelatedWork W2051333776 @default.
- W2058543943 hasRelatedWork W2056413798 @default.
- W2058543943 hasRelatedWork W2094706086 @default.
- W2058543943 hasRelatedWork W2094992908 @default.
- W2058543943 hasRelatedWork W2143730974 @default.
- W2058543943 hasRelatedWork W2565664773 @default.
- W2058543943 hasRelatedWork W2805999712 @default.
- W2058543943 isParatext "false" @default.
- W2058543943 isRetracted "false" @default.
- W2058543943 magId "2058543943" @default.
- W2058543943 workType "article" @default.