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• W2058546812 abstract "Abstract Peripherin is a type III neuronal intermediate filament detected in motor neuron inclusions of amyotrophic lateral sclerosis (ALS) patients. We previously reported that overexpression of peripherin provokes late‐onset motor neuron dysfunction in transgenic mice. Here, we show that peripherin overexpression slows down axonal transport of neurofilament (NF) proteins, and that the transport defect precedes by several months the appearance of axonal spheroids in adult mice. Defective NF transport by peripherin up‐regulation was further confirmed with dorsal root ganglia (DRG) neurons cultured from peripherin transgenic embryos. Immunofluorescence microscopy and western blotting revealed that excess peripherin provokes reduction in levels of hyperphosphorylated NF‐H species in DRG neurites. Similarly the transport of a green fluorescent protein (GFP)‐tagged NF‐M, delivered by means of a lentiviral construct, was impaired in DRG neurites overexpressing peripherin. These results demonstrate that peripherin overexpression can cause defective transport of type IV NF proteins, a phenomenon that may account for the progressive formation of ALS‐like spheroids in axons." @default.
• W2058546812 created "2016-06-24" @default.
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• W2058546812 creator A5091664460 @default.
• W2058546812 date "2006-06-19" @default.
• W2058546812 modified "2023-10-15" @default.
• W2058546812 title "Defective axonal transport of neurofilament proteins in neurons overexpressing peripherin" @default.
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• W2058546812 cites W1527155761 @default.
• W2058546812 cites W1549911944 @default.
• W2058546812 cites W1573139030 @default.
• W2058546812 cites W1592357554 @default.
• W2058546812 cites W1592463385 @default.
• W2058546812 cites W1598099146 @default.
• W2058546812 cites W1646349788 @default.
• W2058546812 cites W1660649612 @default.
• W2058546812 cites W1748991976 @default.
• W2058546812 cites W1814239271 @default.
• W2058546812 cites W1861316716 @default.
• W2058546812 cites W1928513416 @default.
• W2058546812 cites W1969465381 @default.
• W2058546812 cites W1976355798 @default.
• W2058546812 cites W1978932408 @default.
• W2058546812 cites W1979917955 @default.
• W2058546812 cites W1986234504 @default.
• W2058546812 cites W1993845458 @default.
• W2058546812 cites W1994480608 @default.
• W2058546812 cites W1994730834 @default.
• W2058546812 cites W1997763110 @default.
• W2058546812 cites W2003301707 @default.
• W2058546812 cites W2008563656 @default.
• W2058546812 cites W2009761723 @default.
• W2058546812 cites W2011575330 @default.
• W2058546812 cites W2012016770 @default.
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• W2058546812 cites W2017222498 @default.
• W2058546812 cites W2018726628 @default.
• W2058546812 cites W2021547299 @default.
• W2058546812 cites W2022367303 @default.
• W2058546812 cites W2033087568 @default.
• W2058546812 cites W2034334262 @default.
• W2058546812 cites W2036377561 @default.
• W2058546812 cites W2037024974 @default.
• W2058546812 cites W2037786650 @default.
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• W2058546812 cites W2079474271 @default.
• W2058546812 cites W2080862608 @default.
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• W2058546812 cites W2148071983 @default.
• W2058546812 cites W2165716325 @default.
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• W2058546812 doi "https://doi.org/10.1111/j.1471-4159.2006.03932.x" @default.
• W2058546812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16787413" @default.
• W2058546812 hasPublicationYear "2006" @default.
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