FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058549612> ?p ?o ?g. }

• W2058549612 endingPage "1011" @default.
• W2058549612 startingPage "1002" @default.
• W2058549612 abstract "It is known that UV modulates the expression of paracrine factors that regulate melanocyte function in the skin. We investigated the consequences of repetitive UV exposure of human skin in biopsies of 10 subjects with phototypes 2-3.5 taken 1-4 years later. The expression of melanogenic factors (TYR, MART1, MITF), growth factors/receptors (SCF/KIT, bFGF/FGFR1, ET1/EDNRB, HGF, GM-CSF), adhesion molecules (beta-catenin, E-cadherin, N-cadherin), cell cycle proteins (PCNA, cyclins D1, E2) as well as Bcl-2, DKK1, and DKK3, were analyzed by immunohistochemistry. Most of those markers showed no detectable changes at > or = 1 year after the repetitive UV irradiation. Although increased expression of EDNRB protein was detected in 3 of 10 UV-irradiated subjects, there was no detectable change in the expression of ET1 protein or in EDNRB mRNA levels. In summary, only the expression of TYR, MART1, and/or EDNRB, and only in some subjects, was elevated at > or = 1 year after UV irradiation. Thus the long-term effects of repetitive UV irradiation on human skin did not lead to significant changes in skin morphology and there is considerable subject-to-subject variation in responses. The possibility that changes in the expression and function of EDNRB triggers downstream activation of abnormal melanocyte proliferation and differentiation deserves further investigation." @default.
• W2058549612 created "2016-06-24" @default.
• W2058549612 creator A5007258208 @default.
• W2058549612 creator A5016305846 @default.
• W2058549612 creator A5031862428 @default.
• W2058549612 creator A5045895420 @default.
• W2058549612 creator A5060516703 @default.
• W2058549612 creator A5067621120 @default.
• W2058549612 creator A5073538962 @default.
• W2058549612 date "2009-04-01" @default.
• W2058549612 modified "2023-09-27" @default.
• W2058549612 title "Long-Lasting Molecular Changes in Human Skin after Repetitive In Situ UV Irradiation" @default.
• W2058549612 cites W1511251378 @default.
• W2058549612 cites W1588073066 @default.
• W2058549612 cites W1651215666 @default.
• W2058549612 cites W1842784231 @default.
• W2058549612 cites W1856990953 @default.
• W2058549612 cites W1861331149 @default.
• W2058549612 cites W1927159838 @default.
• W2058549612 cites W1949238489 @default.
• W2058549612 cites W1971050728 @default.
• W2058549612 cites W1972031617 @default.
• W2058549612 cites W1976436046 @default.
• W2058549612 cites W1982571441 @default.
• W2058549612 cites W1986395084 @default.
• W2058549612 cites W1987721083 @default.
• W2058549612 cites W1988489437 @default.
• W2058549612 cites W1995030340 @default.
• W2058549612 cites W1995076534 @default.
• W2058549612 cites W1999706643 @default.
• W2058549612 cites W1999992556 @default.
• W2058549612 cites W2003258166 @default.
• W2058549612 cites W2004156002 @default.
• W2058549612 cites W2004480044 @default.
• W2058549612 cites W2010980929 @default.
• W2058549612 cites W2012846873 @default.
• W2058549612 cites W2013109171 @default.
• W2058549612 cites W2018279980 @default.
• W2058549612 cites W2020055953 @default.
• W2058549612 cites W2025479517 @default.
• W2058549612 cites W2030090912 @default.
• W2058549612 cites W2036500143 @default.
• W2058549612 cites W2045250453 @default.
• W2058549612 cites W2046161068 @default.
• W2058549612 cites W2047215045 @default.
• W2058549612 cites W2048566663 @default.
• W2058549612 cites W2051553254 @default.
• W2058549612 cites W2052156954 @default.
• W2058549612 cites W2060655489 @default.
• W2058549612 cites W2063764814 @default.
• W2058549612 cites W2064520370 @default.
• W2058549612 cites W2066078477 @default.
• W2058549612 cites W2071878863 @default.
• W2058549612 cites W2073549690 @default.
• W2058549612 cites W2075951005 @default.
• W2058549612 cites W2080313922 @default.
• W2058549612 cites W2082224552 @default.
• W2058549612 cites W2088574304 @default.
• W2058549612 cites W2089789644 @default.
• W2058549612 cites W2093469127 @default.
• W2058549612 cites W2094397925 @default.
• W2058549612 cites W2098430250 @default.
• W2058549612 cites W2119374868 @default.
• W2058549612 cites W2133142994 @default.
• W2058549612 cites W2135053503 @default.
• W2058549612 cites W2135672013 @default.
• W2058549612 cites W2138112259 @default.
• W2058549612 cites W2138530283 @default.
• W2058549612 cites W2139704092 @default.
• W2058549612 cites W2147772320 @default.
• W2058549612 cites W2147898185 @default.
• W2058549612 cites W2157452165 @default.
• W2058549612 cites W2158199616 @default.
• W2058549612 cites W2167110621 @default.
• W2058549612 cites W2284118197 @default.
• W2058549612 cites W2340387843 @default.
• W2058549612 cites W2397979146 @default.
• W2058549612 cites W2411052517 @default.
• W2058549612 cites W3167326498 @default.
• W2058549612 doi "https://doi.org/10.1038/jid.2008.325" @default.
• W2058549612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2709208" @default.
• W2058549612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18946495" @default.
• W2058549612 hasPublicationYear "2009" @default.
• W2058549612 type Work @default.
• W2058549612 sameAs 2058549612 @default.
• W2058549612 citedByCount "26" @default.
• W2058549612 countsByYear W20585496122015 @default.
• W2058549612 countsByYear W20585496122016 @default.
• W2058549612 countsByYear W20585496122017 @default.
• W2058549612 countsByYear W20585496122018 @default.
• W2058549612 countsByYear W20585496122019 @default.
• W2058549612 countsByYear W20585496122020 @default.
• W2058549612 countsByYear W20585496122021 @default.
• W2058549612 countsByYear W20585496122022 @default.
• W2058549612 crossrefType "journal-article" @default.
• W2058549612 hasAuthorship W2058549612A5007258208 @default.
• W2058549612 hasAuthorship W2058549612A5016305846 @default.
• W2058549612 hasAuthorship W2058549612A5031862428 @default.

• next