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- W2058552632 abstract "Specificity data for groups of transcription factors (TFs) in a common regulatory network can be used to computationally identify the location of cis -regulatory modules in a genome. The primary limitation for this type of analysis is the paucity of specificity data that is available for the majority of TFs. We describe an omega-based bacterial one-hybrid system that provides a rapid method for characterizing DNA-binding specificities on a genome-wide scale. Using this system, 35 members of the Drosophila melanogaster segmentation network have been characterized, including representative members of all of the major classes of DNA-binding domains. A suite of web-based tools was created that uses this binding site dataset and phylogenetic comparisons to identify cis -regulatory modules throughout the fly genome. These tools allow specificities for any combination of factors to be used to perform rapid local or genome-wide searches for cis -regulatory modules. The utility of these factor specificities and tools is demonstrated on the well-characterized segmentation network. By incorporating specificity data on an additional 66 factors that we have characterized, our tools utilize ∼ 14% of the predicted factors within the fly genome and provide an important new community resource for the identification of cis -regulatory modules." @default.
- W2058552632 created "2016-06-24" @default.
- W2058552632 creator A5005165370 @default.
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- W2058552632 date "2008-03-10" @default.
- W2058552632 modified "2023-10-03" @default.
- W2058552632 title "A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system" @default.
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- W2058552632 doi "https://doi.org/10.1093/nar/gkn048" @default.
- W2058552632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2377422" @default.
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