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• W2058553982 abstract "neu­ ropil which may be either white or grey matter. Functional regeneration is a corollary defined as the invasion of regenerating fibres into the original or new targets, where synaptic connections are established which restore lost function. Regeneration ofaxons in the mammalian and avian eNS is, however, largely impossible, but the reasons for this are unknown. The classical accounts of the injury response of eNS axons describe an initial abortive regenerative phase last­ ing up to 14 days, after which growth stops and most fibres die back into the lesion area.! The idea that the scar tissue deposited in the wound acts as a physical barrier, obstruct­ ing the growth trajectory to the target,2-5 is contraindicated by an absence of neuromata on the proximal side of the scar, except in very rare instances.6 The once strongly held view that mature eNS axons are inherently incapable of regrowth beyond the abortive post-injury response! has been refuted by Richardson et aC who showed that neu­ rons from most, if not all, eNS areas regenerate their axons into peripheral nervous system (PNS) grafts implanted into the brain, the spinal cord, and also onto the cut retinal stump of the optic nerve8 (Fig. 1). These findings represent a milestone in the history of regenerative research, not only by showing that eNS axons can regrow, but also in defining a feasible strategy for future research, with a new priority directed towards discovering what it is about the environment of the eNS, on the one hand, which impedes regrowth, and of the PNS, on the other, which promotes regeneration. Subsequently, at least two plausible explanations (which may not be mutually exclusive) were proposed for the growth arrest which underlies the failure of eNS axons to regenerate. First, it was once thought that neurotrophic factors, essential for sustaining fibre growth during development and also mandatory for regeneration, were absent from the mature eNS. Growth-promoting substrates may also be" @default.
• W2058553982 created "2016-06-24" @default.
• W2058553982 creator A5003282551 @default.
• W2058553982 creator A5004194487 @default.
• W2058553982 creator A5037463929 @default.
• W2058553982 creator A5091142233 @default.
• W2058553982 date "1994-03-01" @default.
• W2058553982 modified "2023-10-18" @default.
• W2058553982 title "Axonal growth and its inhibition" @default.
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• W2058553982 doi "https://doi.org/10.1038/eye.1994.53" @default.
• W2058553982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7958029" @default.
• W2058553982 hasPublicationYear "1994" @default.
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