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- W2058555785 abstract "The kidney regulates body fluid, ion and acid/base homeostasis through the interaction of a host of channels, transporters and pumps within specific tubule segments, specific cell types and specific plasma membrane domains. Furthermore, renal epithelial cells have adapted to function in an often unique and challenging environment that includes high medullary osmolality, acidic pHs, variable blood flow and constantly changing apical and basolateral 'bathing' solutions. In this review, we focus on selected protein trafficking events by which kidney epithelial cells regulate body fluid, ion and acid-base homeostasis in response to changes in physiological conditions. We discuss aquaporin 2 and G-protein-coupled receptors in fluid and ion balance, the vacuolar H(+)-adenosine triphosphatase (V-ATPase) and intercalated cells in acid/base regulation and acidification events in the proximal tubule degradation pathway. Finally, in view of its direct role in vesicle trafficking that we outline in this study, we propose that the V-ATPase itself should, under some circumstances, be considered a fourth category of vesicle 'coat' protein (COP), alongside clathrin, caveolin and COPs." @default.
- W2058555785 created "2016-06-24" @default.
- W2058555785 creator A5005756926 @default.
- W2058555785 creator A5042453107 @default.
- W2058555785 creator A5079548777 @default.
- W2058555785 creator A5087672907 @default.
- W2058555785 date "2009-02-05" @default.
- W2058555785 modified "2023-10-13" @default.
- W2058555785 title "Sensing, Signaling and Sorting Events in Kidney Epithelial Cell Physiology" @default.
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- W2058555785 doi "https://doi.org/10.1111/j.1600-0854.2008.00867.x" @default.
- W2058555785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2896909" @default.
- W2058555785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19170982" @default.
- W2058555785 hasPublicationYear "2009" @default.
- W2058555785 type Work @default.