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• W2058556551 abstract "Summary Acute lymphoblastic leukaemia in children with Down syndrome (ALL‐DS) is characterised by unique clinical and biological features. Notable among these are an absence of ALL in DS patients <1 year of age; a lower incidence of favourable and unfavourable chromosomal translocations; heightened sensitivity to methotrexate; and an increased propensity to infections. Although children with ALL‐DS have historically fared less well than their non‐DS counterparts (ALL‐NDS), recent data indicate that outcomes in ALL‐DS are now comparable with ALL‐NDS with risk‐adapted therapies, after adjusting for biological differences between the ALL‐DS and ALL‐NDS populations. Given the increased risk of ALL‐DS patients for treatment‐related toxicities, further intensification of therapy may not yield continued improvements in survival. Future investigations in the ALL‐DS population should focus on maintaining excellent outcomes while reducing treatment‐related complications through novel treatment strategies, such as the integration of targeted noncytotoxic agents." @default.
• W2058556551 created "2016-06-24" @default.
• W2058556551 creator A5085057434 @default.
• W2058556551 date "2006-11-01" @default.
• W2058556551 modified "2023-10-16" @default.
• W2058556551 title "Down syndrome and acute lymphoblastic leukaemia" @default.
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• W2058556551 doi "https://doi.org/10.1111/j.1365-2141.2006.06337.x" @default.
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