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• W2058558185 abstract "<h3>Background</h3> Although risk factors for Alzheimer disease have been well studied, much less is known about risk factors for primary progressive aphasia (PPA). <h3>Objective</h3> To demonstrate that learning disabilities (LDs) are more common in patients with PPA and their first-degree family members. <h3>Design, Setting, and Patients</h3> Self-report endorsement of an individual and family history of an LD in a sample of 699 subjects from the Northwestern Alzheimer's Disease Center registry. We compared 3 dementia groups (PPA, typical amnestic Alzheimer disease, and the behavioral variant of frontotemporal dementia) and 1 elderly control group. A retrospective medical record review in the PPA probands was used to obtain additional information. <h3>Main Outcome Measure</h3> Prevalence of LDs among probands and their first-degree relatives. <h3>Results</h3> The patients with PPA and their first-degree family members had a significantly higher frequency of LD compared with the other dementia groups and the controls. Some of the families of patients with PPA displayed unusual concentrations of LD, especially dyslexia. <h3>Conclusion</h3> These results suggest that LD may constitute a risk factor for PPA, providing additional clues concerning the determinants for the selective vulnerability of the language network in this syndrome." @default.
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• W2058558185 date "2008-02-01" @default.
• W2058558185 modified "2023-09-27" @default.
• W2058558185 title "Increased Frequency of Learning Disability in Patients With Primary Progressive Aphasia and Their First-Degree Relatives" @default.
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• W2058558185 doi "https://doi.org/10.1001/archneurol.2007.34" @default.
• W2058558185 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2892116" @default.
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